A | B | C | D | E | F | G | H | CH | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 0 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9
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Trade names | Artalan, Dartal, Dartalan, Dartan |
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KEGG |
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ECHA InfoCard | 100.001.376 |
Chemical and physical data | |
Formula | C23H28ClN3O2S |
Molar mass | 446.01 g·mol−1 |
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Thiopropazate (Artalan, Dartal, Dartalan, Dartan) is a typical antipsychotic of the phenothiazine class.[1] It is a prodrug to perphenazine.
Thiopropazate is manufactured by Searle (US, UK) & Boehringer Mannheim (Germany)[2] Thiopropazate is sold by Chembase, AAA Chemistry, ZINC, AKos Consulting & Solutions, Boc Sciences, ChemFrog, and ChemMol[3]
Synthesisedit
The alkylation of 2-chloro-10-(3-chloropropyl)phenothiazine 2765-59-5 (1) with Piperazine (2) gives N-Desmethylprochlorperazine 40323-85-1 (3). Further alkylation with 2-Bromoethyl acetate 927-68-4 (4) gives Thiopropazate (5).
See alsoedit
Referencesedit
- ^ Buckingham J (1996). Dictionary of organic compounds. London: Chapman & Hall. p. 5148. ISBN 0-412-54090-8.
- ^ Pharmaceutical Manufacturing Encyclopedia p. 3209
- ^ "Thiopropazate". PubChem. United States Library of Medicine.
- ^ John W Cusic, U.S. patent 2,766,235 (1956 to Searle & Co).
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