A | B | C | D | E | F | G | H | CH | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 0 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9
Names | |
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IUPAC name
(RS)-2-4-(2-methyl-3-phenothiazin-10-ylpropyl)piperazin-1-ylethoxyethanol
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Other names
UCB-3412
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Identifiers | |
3D model (JSmol)
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ChemSpider | |
ECHA InfoCard | 100.017.811 |
EC Number |
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KEGG | |
PubChem CID
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
C24H33N3O2S | |
Molar mass | 427.60272 g/mol |
Pharmacology | |
N05AB01 (WHO) | |
Legal status | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C 77 °F, 100 kPa).
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Dixyrazine, also known as dixypazin (oxalate), sold under the brand names Ansiolene, Esocalm, Esucos, Metronal, and Roscal, is a typical antipsychotic of the phenothiazine group described as a neuroleptic and antihistamine.[2] It was first introduced in Germany in 1969. It is used as a neuroleptic, anxiolytic, and antihistamine in doses between 12.5 and 75 mg a day.
Synthesisedit
Sodamide alkylation of phenothiazine (1) with 1-bromo-3-chloro-2-methylpropane 6974-77-2 (2) gives 10-(3-Chloro-2-methylpropyl)phenothiazine, CID:12299119 (3). Completion of the sidechain by alkylation with 1-2-(2-Hydroxyethoxy) EthylPiperazine 13349-82-1 (4) and displacement of the halogen completes the synthesis of Dixyrazine (5).
Referencesedit
- ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
- ^ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 462–. ISBN 978-1-4757-2085-3.
- ^ Henri Morren, GB861420 (1961).
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