Tolazoline

Tolazoline
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	IV
ATC code	C04AB02 (WHO) M02AX02 (WHO) QV03AB94 (WHO);
Identifiers
	IUPAC name 2-Benzyl-4,5-dihydro-1H-imidazole;
CAS Number	59-98-3 ;
PubChem CID	5504;
IUPHAR/BPS	7310;
DrugBank	DB00797 ;
ChemSpider	5303 ;
UNII	CHH9H12AQ3;
KEGG	D08614 ;
ChEBI	CHEBI:28502 ;
ChEMBL	ChEMBL770 ;
CompTox Dashboard (EPA)	DTXSID3023683 ;
ECHA InfoCard	100.000.408
Chemical and physical data
Formula	C10H12N2
Molar mass	160.220 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES N\1=C(\NCC/1)Cc2ccccc2;
	InChI InChI=1S/C10H12N2/c1-2-4-9(5-3-1)8-10-11-6-7-12-10/h1-5H,6-8H2,(H,11,12) ; Key:JIVZKJJQOZQXQB-UHFFFAOYSA-N ;
	(verify)

Tolazoline is a non-selective competitive α-adrenergic receptor antagonist.^[1] It is a vasodilator that is used to treat spasms of peripheral blood vessels (as in acrocyanosis). It has also been used (in conjunction with sodium nitroprusside) successfully as an antidote to reverse the severe peripheral vasoconstriction which can occur as a result of overdose with certain 5-HT_2A agonist drugs such as 25I-NBOMe,^[2] DOB and Bromodragonfly (prolonged severe vasoconstriction can lead to gangrene if untreated).^[3]^[4]

It is however most commonly used in veterinary medicine, to reverse xylazine-induced sedation.^[5]^[6]

References

^ Aronson, J. K. (2016). Meyler's side effects of drugs : the international encyclopedia of adverse drug reactions and interactions. Amsterdam: Elsevier Science. ISBN 978-0-444-53717-1. OCLC 927102885. Tolazoline is an α2 adrenoceptor antagonist that increases skin blood flow in healthy subjects and has been used to relieve acute vasospasm.
^ "Human Metabolome Database: Showing metabocard for Tolazoline (HMDB0014935)". hmdb.ca. Retrieved 2022-02-03.
^ Bowen JS, Davis GB, Kearney TE, Bardin J (March 1983). "Diffuse vascular spasm associated with 4-bromo-2,5-dimethoxyamphetamine ingestion". JAMA. 249 (11): 1477–9. doi:10.1001/jama.1983.03330350053028. PMID 6827726.
^ Thorlacius K, Borna C, Personne M (2008). "". Läkartidningen (in Swedish). 105 (16): 1199–200. PMID 18522262.
^ Boothe DM (2001). "Anticonvulsant drugs and analeptic agents". In Adams HR (ed.). Veterinary pharmacology and therapeutics. Ames: Iowa State University Press. pp. 378–9. ISBN 0-8138-1743-9. Retrieved 8 September 2008.
^ Hall LW, Clarke KW, Trim CM (2001). "Principles of sedation, analgesia and premedication". Veterinary anaesthesia. Philadelphia: W.B. Saunders. pp. 90–1. ISBN 0-7020-2035-4.

Zdroj:https://en.wikipedia.org?pojem=Tolazoline
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[Aronson_2016_p.-1] Aronson, J. K. (2016). Meyler's side effects of drugs : the international encyclopedia of adverse drug reactions and interactions. Amsterdam: Elsevier Science. ISBN 978-0-444-53717-1. OCLC 927102885. Tolazoline is an α2 adrenoceptor antagonist that increases skin blood flow in healthy subjects and has been used to relieve acute vasospasm.

[2] "Human Metabolome Database: Showing metabocard for Tolazoline (HMDB0014935)". hmdb.ca. Retrieved 2022-02-03.

[pmid6827726-3] Bowen JS, Davis GB, Kearney TE, Bardin J (March 1983). "Diffuse vascular spasm associated with 4-bromo-2,5-dimethoxyamphetamine ingestion". JAMA. 249 (11): 1477–9. doi:10.1001/jama.1983.03330350053028. PMID 6827726.

[pmid18522262-4] Thorlacius K, Borna C, Personne M (2008). "". Läkartidningen (in Swedish). 105 (16): 1199–200. PMID 18522262.

[5] Boothe DM (2001). "Anticonvulsant drugs and analeptic agents". In Adams HR (ed.). Veterinary pharmacology and therapeutics. Ames: Iowa State University Press. pp. 378–9. ISBN 0-8138-1743-9. Retrieved 8 September 2008.

[6] Hall LW, Clarke KW, Trim CM (2001). "Principles of sedation, analgesia and premedication". Veterinary anaesthesia. Philadelphia: W.B. Saunders. pp. 90–1. ISBN 0-7020-2035-4.

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v t e Peripheral vasodilators (C04)
Phenylethanolamine derivatives	Isoxsuprine Buphenine Bamethan
Alpha blockers	Non-selective Buflomedil Phentolamine Phenoxybenzamine Tolazoline Selective α₁-blockers Alfuzosin Doxazosin Prazosin Silodosin Tamsulosin Terazosin
Niacin and derivatives	Niacin Nicotinyl alcohol Inositol nicotinate Ciclonicate
Purine derivatives	Pentifylline Xantinol nicotinate Pentoxifylline Etofylline nicotinate
Ergot alkaloids	Ergoloid Nicergoline Dihydroergocristine
Other peripheral vasodilators	Cyclandelate Vincamine Moxisylyte Bencyclane Vinburnine Sulcotidil Naftidrofuryl Butalamine Visnadine Cetiedil Cinepazide Ifenprodil Azapetine Fasudil

Clinical data

AHFS/Drugs.com	International Drug Names
Routes of administration	IV
ATC code	C04AB02 (WHO) M02AX02 (WHO) QV03AB94 (WHO)
Identifiers
IUPAC name 2-Benzyl-4,5-dihydro-1H-imidazole
CAS Number	59-98-3^Y
PubChem CID	5504
IUPHAR/BPS	7310
DrugBank	DB00797^Y
ChemSpider	5303^Y
UNII	CHH9H12AQ3
KEGG	D08614^Y
ChEBI	CHEBI:28502^Y
ChEMBL	ChEMBL770^Y
CompTox Dashboard (EPA)	DTXSID3023683
ECHA InfoCard	100.000.408
Chemical and physical data
Formula	C₁₀H₁₂N₂
Molar mass	160.220 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES N\1=C(\NCC/1)Cc2ccccc2
InChI InChI=1S/C10H12N2/c1-2-4-9(5-3-1)8-10-11-6-7-12-10/h1-5H,6-8H2,(H,11,12)^Y Key:JIVZKJJQOZQXQB-UHFFFAOYSA-N^Y
(verify)