Domesticine

Domesticine
Names
	IUPAC name 2-Methoxy-2′H-dioxoloaporphin-1-ol
	Systematic IUPAC name (6aS)-2-Methoxy-6-methyl-5,6,6a,7-tetrahydro-4H,10H-benzobenzodioxoloquinolin-1-ol
Identifiers
CAS Number	476-71-1 ;
3D model (JSmol)	Interactive image;
ChemSpider	144307;
PubChem CID	164611;
UNII	96P7649HX8 ;
CompTox Dashboard (EPA)	DTXSID50197217 ;
	InChI InChI=1S/C19H19NO4/c1-20-4-3-10-6-16(22-2)19(21)18-12-8-15-14(23-9-24-15)7-11(12)5-13(20)17(10)18/h6-8,13,21H,3-5,9H2,1-2H3/t13-/m0/s1 Key: ZMNSHBTYBQNBPV-ZDUSSCGKSA-N;
	SMILES CN1CCC2=CC(=C(C3=C21CC4=CC5=C(C=C43)OCO5)O)OC;
Properties
Chemical formula	C19H19NO4
Molar mass	325.364 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Infobox references

Domesticine is an α_1D-adrenergic receptor antagonist.^[1] The compound belongs to the group of Aporphine alkaloids.

References

^ Indra, B; Matsunaga, K; Hoshino, O; Suzuki, M; Ogasawara, H; Muramatsu, I; Taniguchi, T; Ohizumi, Y (2002). "(+/-)-Domesticine, a novel and selective alpha1D-adrenoceptor antagonist in animal tissues and human alpha 1-adrenoceptors". European Journal of Pharmacology. 445 (1–2): 21–9. doi:10.1016/s0014-2999(02)01601-1. PMID 12065190.

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[1] Indra, B; Matsunaga, K; Hoshino, O; Suzuki, M; Ogasawara, H; Muramatsu, I; Taniguchi, T; Ohizumi, Y (2002). "(+/-)-Domesticine, a novel and selective alpha1D-adrenoceptor antagonist in animal tissues and human alpha 1-adrenoceptors". European Journal of Pharmacology. 445 (1–2): 21–9. doi:10.1016/s0014-2999(02)01601-1. PMID 12065190.

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