BRL-44408

BRL-44408
Identifiers
	IUPAC name 2--2,3-dihydro-1-methyl-1H-isoindole;
CAS Number	118343-19-4 ;
PubChem CID	121850;
IUPHAR/BPS	525;
ChemSpider	108707 ;
UNII	ZET7B198W2;
ChEMBL	ChEMBL216097 ;
CompTox Dashboard (EPA)	DTXSID30922665 ;
Chemical and physical data
Formula	C13H17N3
Molar mass	215.300 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES N2CCN=C2CN(C1C)Cc3c1cccc3;
	InChI InChI=1S/C13H17N3/c1-10-12-5-3-2-4-11(12)8-16(10)9-13-14-6-7-15-13/h2-5,10H,6-9H2,1H3,(H,14,15) ; Key:SGOFAUSEYBZKDQ-UHFFFAOYSA-N ;
	(what is this?) (verify)

BRL-44408 is a drug used in scientific research which acts as a selective antagonist for the α_2A adrenoreceptor.^[1] It has been suggested as having potential therapeutic application in the treatment of extrapyramidal side effects produced by some antipsychotic medications.^[2]

References

^ Alberts P (January 1993). "Subtype classification of presynaptic alpha 2-adrenoceptors". General Pharmacology. 24 (1): 1–8. doi:10.1016/0306-3623(93)90003-g. PMID 8387042.
^ Imaki J, Mae Y, Shimizu S, Ohno Y (April 2009). "Therapeutic potential of alpha2 adrenoceptor antagonism for antipsychotic-induced extrapyramidal motor disorders". Neuroscience Letters. 454 (2): 143–7. doi:10.1016/j.neulet.2009.03.001. PMID 19429072. S2CID 38109591.

External links

Media related to BRL-44408 at Wikimedia Commons

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[pmid8387042-1] Alberts P (January 1993). "Subtype classification of presynaptic alpha 2-adrenoceptors". General Pharmacology. 24 (1): 1–8. doi:10.1016/0306-3623(93)90003-g. PMID 8387042.

[pmid19429072-2] Imaki J, Mae Y, Shimizu S, Ohno Y (April 2009). "Therapeutic potential of alpha2 adrenoceptor antagonism for antipsychotic-induced extrapyramidal motor disorders". Neuroscience Letters. 454 (2): 143–7. doi:10.1016/j.neulet.2009.03.001. PMID 19429072. S2CID 38109591.

[1]

[2]

Identifiers

IUPAC name 2--2,3-dihydro-1-methyl-1H-isoindole
CAS Number	118343-19-4^Y
PubChem CID	121850
IUPHAR/BPS	525
ChemSpider	108707^N
UNII	ZET7B198W2
ChEMBL	ChEMBL216097^N
CompTox Dashboard (EPA)	DTXSID30922665
Chemical and physical data
Formula	C₁₃H₁₇N₃
Molar mass	215.300 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES N2CCN=C2CN(C1C)Cc3c1cccc3
InChI InChI=1S/C13H17N3/c1-10-12-5-3-2-4-11(12)8-16(10)9-13-14-6-7-15-13/h2-5,10H,6-9H2,1H3,(H,14,15)^N Key:SGOFAUSEYBZKDQ-UHFFFAOYSA-N^N
^NY (what is this?) (verify)