Moxisylyte

Moxisylyte
Clinical data
Other names	Thymoxamine
AHFS/Drugs.com	International Drug Names
ATC code	G04BE06 (WHO) C04AX10 (WHO);
Identifiers
	IUPAC name 4--5-isopropyl-2-methylphenyl acetate;
CAS Number	54-32-0 ;
PubChem CID	4260;
DrugBank	DB09205 ;
ChemSpider	4110;
UNII	PW8QYA7KI0;
KEGG	D08239 ;
CompTox Dashboard (EPA)	DTXSID4023339 ;
ECHA InfoCard	100.000.186
Chemical and physical data
Formula	C16H25NO3
Molar mass	279.380 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1=CC(=C(C=C1OC(=O)C)C(C)C)OCCN(C)C;
	InChI InChI=1S/C16H25NO3/c1-11(2)14-10-15(20-13(4)18)12(3)9-16(14)19-8-7-17(5)6/h9-11H,7-8H2,1-6H3; Key:VRYMTAVOXVTQEF-UHFFFAOYSA-N;
	(verify)

Moxisylyte, also known as thymoxamine, is a drug used in urology for the treatment of erectile dysfunction.^[1] It is an α₁-adrenergic antagonist.^[2] In the United Kingdom, Moxisylte is marketed as Opilon (Archimedes Pharma UK Ltd) and is used for the short-term treatment of primary Raynaud's syndrome. This is a condition where the fingers and toes become discoloured and is triggered by responses to cold, or emotional distress. Opilon tablets help by improving blood circulation to the extremities.^[3]^[4]

References

^ British National Formulary 69, Chapter2.6.4, page 142
^ Sakakibara R, Hattori T, Uchiyama T, et al. (March 2000). "Are alpha-blockers involved in lower urinary tract dysfunction in multiple system atrophy? A comparison of prazosin and moxisylyte". J. Auton. Nerv. Syst. 79 (2–3): 191–5. doi:10.1016/S0165-1838(99)00105-8. PMID 10699651.
^ British National Formulary 70, page 205
^ "Opilon tablets - Patient Information Leaflet (PIL) - (eMC)". www.medicines.org.uk.

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[1] British National Formulary 69, Chapter2.6.4, page 142

[pmid10699651-2] Sakakibara R, Hattori T, Uchiyama T, et al. (March 2000). "Are alpha-blockers involved in lower urinary tract dysfunction in multiple system atrophy? A comparison of prazosin and moxisylyte". J. Auton. Nerv. Syst. 79 (2–3): 191–5. doi:10.1016/S0165-1838(99)00105-8. PMID 10699651.

[3] British National Formulary 70, page 205

[4] "Opilon tablets - Patient Information Leaflet (PIL) - (eMC)". www.medicines.org.uk.

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v t e Peripheral vasodilators (C04)
Phenylethanolamine derivatives	Isoxsuprine Buphenine Bamethan
Alpha blockers	Non-selective Buflomedil Phentolamine Phenoxybenzamine Tolazoline Selective α₁-blockers Alfuzosin Doxazosin Prazosin Silodosin Tamsulosin Terazosin
Niacin and derivatives	Niacin Nicotinyl alcohol Inositol nicotinate Ciclonicate
Purine derivatives	Pentifylline Xantinol nicotinate Pentoxifylline Etofylline nicotinate
Ergot alkaloids	Ergoloid Nicergoline Dihydroergocristine
Other peripheral vasodilators	Cyclandelate Vincamine Moxisylyte Bencyclane Vinburnine Sulcotidil Naftidrofuryl Butalamine Visnadine Cetiedil Cinepazide Ifenprodil Azapetine Fasudil