Dinoxyline

Dinoxyline
Clinical data
ATC code	none;
Identifiers
	IUPAC name 8,9-dihydroxy-1,2,3,11b-tetrahydrochromenoisoquinoline;
CAS Number	757176-96-8 ;
PubChem CID	9819126;
ChemSpider	7994875;
UNII	9T7B8CV47A;
Chemical and physical data
Formula	C15H13NO3
Molar mass	255.273 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES c3ccc(Oc24)c1c3CNCC1c4ccc(O)c2O;
	InChI InChI=1S/C15H13NO3/c17-11-5-4-9-10-7-16-6-8-2-1-3-12(13(8)10)19-15(9)14(11)18/h1-5,10,16-18H,6-7H2; Key:QOHSTVKJXZTEOL-UHFFFAOYSA-N;
	(verify)

Dinoxyline is a synthetic compound developed for scientific research, which acts as a potent full agonist at all five dopamine receptor subtypes.^[1]^[2]^[3]

References

^ Grubbs RA, Lewis MM, Owens-Vance C, Gay EA, Jassen AK, Mailman RB, Nichols DE (March 2004). "8,9-dihydroxy-1,2,3,11b-tetrahydrochromenoisoquinoline (dinoxyline), a high affinity and potent agonist at all dopamine receptor isoforms". Bioorganic & Medicinal Chemistry. 12 (6): 1403–12. doi:10.1016/j.bmc.2004.01.008. PMID 15018913.
^ Ryman-Rasmussen JP, Nichols DE, Mailman RB (October 2005). "Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists". Molecular Pharmacology. 68 (4): 1039–48. doi:10.1124/mol.105.012153. PMID 15985612. S2CID 14398107.
^ Zhang J, Xiong B, Zhen X, Zhang A (March 2009). "Dopamine D1 receptor ligands: where are we now and where are we going". Medicinal Research Reviews. 29 (2): 272–94. doi:10.1002/med.20130. PMID 18642350. S2CID 25334596.

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[pmid15018913-1] Grubbs RA, Lewis MM, Owens-Vance C, Gay EA, Jassen AK, Mailman RB, Nichols DE (March 2004). "8,9-dihydroxy-1,2,3,11b-tetrahydrochromenoisoquinoline (dinoxyline), a high affinity and potent agonist at all dopamine receptor isoforms". Bioorganic & Medicinal Chemistry. 12 (6): 1403–12. doi:10.1016/j.bmc.2004.01.008. PMID 15018913.

[pmid15985612-2] Ryman-Rasmussen JP, Nichols DE, Mailman RB (October 2005). "Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists". Molecular Pharmacology. 68 (4): 1039–48. doi:10.1124/mol.105.012153. PMID 15985612. S2CID 14398107.

[pmid18642350-3] Zhang J, Xiong B, Zhen X, Zhang A (March 2009). "Dopamine D1 receptor ligands: where are we now and where are we going". Medicinal Research Reviews. 29 (2): 272–94. doi:10.1002/med.20130. PMID 18642350. S2CID 25334596.

[1]

[2]

[3]

Clinical data

ATC code	none
Identifiers
IUPAC name 8,9-dihydroxy-1,2,3,11b-tetrahydrochromenoisoquinoline
CAS Number	757176-96-8^Y
PubChem CID	9819126
ChemSpider	7994875
UNII	9T7B8CV47A
Chemical and physical data
Formula	C₁₅H₁₃NO₃
Molar mass	255.273 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES c3ccc(Oc24)c1c3CNCC1c4ccc(O)c2O
InChI InChI=1S/C15H13NO3/c17-11-5-4-9-10-7-16-6-8-2-1-3-12(13(8)10)19-15(9)14(11)18/h1-5,10,16-18H,6-7H2 Key:QOHSTVKJXZTEOL-UHFFFAOYSA-N
(verify)