A | B | C | D | E | F | G | H | CH | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 0 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9
Names | |
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IUPAC name
2-Hydroxy-3-4-(4-(trifluoromethyl)phenylmethoxy)phenyl-1,2,3,4-tetrahydronaphthalen-1-yl chromen-4-one
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Identifiers | |
3D model (JSmol)
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ECHA InfoCard | 100.102.053 |
KEGG | |
PubChem CID
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
C33H25F3O4 | |
Molar mass | 542.554 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C 77 °F, 100 kPa).
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Flocoumafen is a fluorinated, second-generation anticoagulant of the 4-hydroxycoumarin vitamin K antagonist type.[1] It is a second generation (i.e., high potency) chemical in this class, used commercially as a rodenticide. It has a very high toxicity and is restricted to indoor use and sewers (in the UK). This restriction is mainly due to the increased risk to non-target species, especially due to its tendency to bio-accumulate in exposed organisms. Studies have shown that rodents resistant to first-generation anticoagulants can be adequately controlled with flocoumafen.[1] It was synthesized in 1984 by Shell International Chemical.[2]
Toxicityedit
In most rodents, the LD50 is 1 mg/kg, but it can vary between species: from 0.12 mg/kg in the common vole (Microtus arvalis) to more than 10 mg/kg in the Cairo spiny mouse (Acomys cahirinus). For dogs the LD50 is 0.075-0.25 mg/kg.[2]
Antidoteedit
The antidote to flocoumafen is vitamin K1, which must be administered over a period of several weeks or even months.[3]
Referencesedit
- ^ a b Watt, Barbara E.; Proudfoot, Alex T.; Bradberry, Sally M.; Vale, J Allister (2005). "Anticoagulant Rodenticides". Toxicological Reviews. 24 (4): 259–269. doi:10.2165/00139709-200524040-00005. PMID 16499407.
- ^ a b Flocoumafen -- A new anticoagulant rodenticide
- ^ "Flocoumafen: Antidote and Emergency Treatment". PubChem.
External linksedit
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