Fixed drug reaction

Fixed drug reaction
Fixed drug reaction
Other names	Drug eruption
	Fixed drug eruption caused by phenolphtalein.
Specialty	Dermatology

Fixed drug reactions are common and so named because they recur at the same site with each exposure to a particular medication.^[1] Medications inducing fixed drug eruptions are usually those taken intermittently.^[1]

Signs and symptoms

A painful and itchy reddish/purple patch of skin that occurs in the same location with repeated exposures to the causative drug is the classic presentation of a fixed drug reaction. The lips, genitals, and hands are often involved.

Cause

Medications that are commonly implicated as a cause of fixed drug eruptions include the following:

Cetirizine
Ciprofloxacin
Clarithromycin
Cotrimoxazole
Doxycycline
Fluconazole
NSAIDs (e.g., ibuprofen, etoricoxib, naproxen)
Phenytoin
Pseudoephedrine^[2]
Trimethoprim

References

^ ^a ^b James W, Berger T, Elston D (2005). Andrews' Diseases of the Skin: Clinical Dermatology (10th ed.). Saunders. p. 127. ISBN 978-0-7216-2921-6.
^ Vidal C, Prieto A, Pérez-Carral C, Armisén M (April 1998). "Nonpigmenting fixed drug eruption due to pseudoephedrine". Annals of Allergy, Asthma & Immunology. 80 (4): 309–310. doi:10.1016/S1081-1206(10)62974-2. PMID 9564979.

External links

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[Andrews-1] James W, Berger T, Elston D (2005). Andrews' Diseases of the Skin: Clinical Dermatology (10th ed.). Saunders. p. 127. ISBN 978-0-7216-2921-6.

[2] Vidal C, Prieto A, Pérez-Carral C, Armisén M (April 1998). "Nonpigmenting fixed drug eruption due to pseudoephedrine". Annals of Allergy, Asthma & Immunology. 80 (4): 309–310. doi:10.1016/S1081-1206(10)62974-2. PMID 9564979.

[1]

[2]

v t e Dermatitis and eczema
Atopic dermatitis	Prurigo gestationis Sweat allergy
Seborrheic dermatitis	Pityriasis simplex capillitii Cradle cap
Contact dermatitis (allergic, irritant)	plants: Urushiol-induced contact dermatitis African blackwood dermatitis Tulip fingers other: Abietic acid dermatitis Diaper rash Airbag dermatitis Baboon syndrome Contact stomatitis Metal allergy Protein contact dermatitis
Eczema	Autoimmune estrogen dermatitis Autoimmune progesterone dermatitis Breast eczema Ear eczema Eyelid dermatitis Topical steroid withdrawal Hand eczema Chronic vesiculobullous hand eczema Hyperkeratotic hand dermatitis Autosensitization dermatitis/Id reaction Candidid Dermatophytid Molluscum dermatitis Circumostomy eczema Dyshidrosis Juvenile plantar dermatosis Nummular eczema Nutritional deficiency eczema Sulzberger–Garbe syndrome Xerotic eczema
Pruritus/Itch/ Prurigo	Lichen simplex chronicus/Prurigo nodularis by location: Pruritus ani Pruritus scroti Pruritus vulvae Scalp pruritus Drug-induced pruritus Hydroxyethyl starch-induced pruritus Senile pruritus Aquagenic pruritus Aquadynia Adult blaschkitis due to liver disease Biliary pruritus Cholestatic pruritus Prion pruritus Prurigo pigmentosa Prurigo simplex Puncta pruritica Uremic pruritus
Other	substances taken internally: Bromoderma Fixed drug reaction Nummular dermatitis Pityriasis alba Papuloerythroderma of Ofuji

Signs and symptoms

Cause

See also

References

External links