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Names | |
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IUPAC name
3,16β-Dihydroxyestra-1,3,5(10)-trien-17-one
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Systematic IUPAC name
(2S,3aS,3bR,9bS,11aS)-2,7-Dihydroxy-11a-methyl-2,3,3a,3b,4,5,9b,10,11,11a-decahydro-1H-cyclopentaphenanthren-1-one | |
Other names
16β-OH-E1
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Identifiers | |
3D model (JSmol)
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ChEBI | |
ChEMBL | |
ChemSpider | |
PubChem CID
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Properties | |
C18H22O3 | |
Molar mass | 286.371 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa).
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16β-Hydroxyestrone (16β-OH-E1) is an endogenous estrogen which serves as a metabolite of estrone as well as a metabolic intermediate in the transformation of estrone into epiestriol (16β-hydroxyestradiol).[1][2] 16β-Hydroxyestrone has similar estrogenic activity to that of 16α-hydroxyestrone.[2] It is less potent than estradiol or estrone but can produce similar maximal uterotrophy at sufficiently high doses, suggesting a fully estrogenic profile.[2]
See also
References
- ^ "16beta-Hydroxyestrone". PubChem.
- ^ a b c Velardo, Joseph Thomas (1964). The Actions of Steroid Hormones on Estradiol-17β in Uterine Growth and Enzymorphology. Hormonal Steroids Biochemistry, Pharmacology, and Therapeutics. pp. 463–490. doi:10.1016/B978-0-12-395506-7.50065-0.
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