A | B | C | D | E | F | G | H | CH | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 0 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9
Prothrombin fragment 1+2 (F1+2), also written as prothrombin fragment 1.2 (F1.2), is a polypeptide fragment of prothrombin (factor II) generated by the in vivo cleavage of prothrombin into thrombin (factor IIa) by the enzyme prothrombinase (a complex of factor Xa and factor Va).[1][2][3] It is released from the N-terminus of prothrombin.[3] F1+2 is a marker of thrombin generation and hence of coagulation activation.[4][3][1] It is considered the best marker of in vivo thrombin generation.[1]
F1+2 levels can be quantified with blood tests and is used in the diagnosis of hyper- and hypocoagulable states and in the monitoring of anticoagulant therapy.[4][1] It was initially determined with a radioimmunoassay, but is now measured with several enzyme-linked immunosorbent assays.[1]
The molecular weight of F1+2 is around 41 to 43 kDa.[4][1] Its biological half-life is 90 minutes and it persists in blood for a few hours after formation.[4][3][1] The half-life of F1+2 is relatively long, which makes it more reliable for measuring ongoing coagulation than other markers like thrombin–antithrombin complexes and fibrinopeptide A.[1][3] Concentrations of F1+2 in healthy individuals range from 0.44 to 1.11 nM.[4]
F1+2 levels increase with age.[3] Levels of F1+2 have been reported to be elevated in venous thromboembolism, protein C deficiency, protein S deficiency, atrial fibrillation, unstable angina, acute myocardial infarction, acute stroke, atherosclerosis, peripheral arterial disease, and in smokers.[3][1] Anticoagulants have been found to reduce F1+2 levels.[1] F1+2 levels are increased with pregnancy[5] and by ethinylestradiol-containing birth control pills.[6] Conversely, they do not appear to be increased with estetrol- or estradiol-containing birth control pills.[6] However, F1+2 levels have been reported to be increased with oral estrogen-based menopausal hormone therapy, whereas transdermal estradiol-based menpausal hormone therapy appears to result in less or no consistent increase.[7]
References
- ^ a b c d e f g h i j Páramo JA (2010). "Prothrombin fragments in cardiovascular disease". Adv Clin Chem. Advances in Clinical Chemistry. 51: 1–23. doi:10.1016/s0065-2423(10)51001-1. ISBN 9780123809810. PMID 20857616.
- ^ Krishnaswamy S (June 2013). "The transition of prothrombin to thrombin". J Thromb Haemost. 11 Suppl 1 (1): 265–76. doi:10.1111/jth.12217. PMC 3713535. PMID 23809130.
- ^ a b c d e f g Merlini PA, Ardissino D (1995). "Laboratory Measurement of Thrombin Activity--What Every Clinician Scientist Needs to Know". J Thromb Thrombolysis. 2 (2): 85–92. doi:10.1007/BF01064374. PMID 10608009. S2CID 28203940.
- ^ a b c d e Dati F, Pelzer H, Wagner C (1998). "Relevance of markers of hemostasis activation in obstetrics/gynecology and pediatrics". Semin Thromb Hemost. 24 (5): 443–8. doi:10.1055/s-2007-996037. PMID 9834011. S2CID 27803157.
- ^ Hellgren M (April 2003). "Hemostasis during normal pregnancy and puerperium". Semin Thromb Hemost. 29 (2): 125–30. doi:10.1055/s-2003-38897. PMID 12709915. S2CID 22082884.
- ^ a b Douxfils J, Morimont L, Bouvy C (November 2020). "Oral Contraceptives and Venous Thromboembolism: Focus on Testing that May Enable Prediction and Assessment of the Risk". Semin Thromb Hemost. 46 (8): 872–886. doi:10.1055/s-0040-1714140. PMID 33080636. S2CID 224821517.
- ^ Hemelaar M, van der Mooren MJ, Rad M, Kluft C, Kenemans P (September 2008). "Effects of non-oral postmenopausal hormone therapy on markers of cardiovascular risk: a systematic review". Fertil Steril. 90 (3): 642–72. doi:10.1016/j.fertnstert.2007.07.1298. PMID 17923128.
Text je dostupný za podmienok Creative Commons Attribution/Share-Alike License 3.0 Unported; prípadne za ďalších podmienok. Podrobnejšie informácie nájdete na stránke Podmienky použitia.
Antropológia
Aplikované vedy
Bibliometria
Dejiny vedy
Encyklopédie
Filozofia vedy
Forenzné vedy
Humanitné vedy
Knižničná veda
Kryogenika
Kryptológia
Kulturológia
Literárna veda
Medzidisciplinárne oblasti
Metódy kvantitatívnej analýzy
Metavedy
Metodika
Text je dostupný za podmienok Creative
Commons Attribution/Share-Alike License 3.0 Unported; prípadne za ďalších
podmienok.
Podrobnejšie informácie nájdete na stránke Podmienky
použitia.
www.astronomia.sk | www.biologia.sk | www.botanika.sk | www.dejiny.sk | www.economy.sk | www.elektrotechnika.sk | www.estetika.sk | www.farmakologia.sk | www.filozofia.sk | Fyzika | www.futurologia.sk | www.genetika.sk | www.chemia.sk | www.lingvistika.sk | www.politologia.sk | www.psychologia.sk | www.sexuologia.sk | www.sociologia.sk | www.veda.sk I www.zoologia.sk