Homatropine methylbromide

Homatropine methylbromide
Clinical data
Other names	Methylhomatropine bromide
ATC code	A03BB06 (WHO) ;
Identifiers
	IUPAC name (N,N-Dimethyl-8-azoniabicyclooct-3-yl) 2-hydroxy-2-phenylacetate bromide;
CAS Number	80-49-9;
PubChem CID	6646;
DrugBank	DB00725;
ChemSpider	6394 ;
UNII	68JRS2HC1C;
KEGG	D02070;
ChEMBL	ChEMBL1200851;
CompTox Dashboard (EPA)	DTXSID4023127 ;
ECHA InfoCard	100.001.168
Chemical and physical data
Formula	C17H24BrNO3
Molar mass	370.287 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1(C2CCC1CC(C2)OC(=O)C(C3=CC=CC=C3)O)C.;
	InChI InChI=1S/C17H24NO3.BrH/c1-18(2)13-8-9-14(18)11-15(10-13)21-17(20)16(19)12-6-4-3-5-7-12;/h3-7,13-16,19H,8-11H2,1-2H3;1H/q+1;/p-1/t13-,14+,15+,16?; ; Key:ZTVIKZXZYLEVOL-MCOXGKPRSA-N ;
	(verify)

Homatropine methylbromide (INN; also known as methylhomatropine bromide) is a quaternary ammonium salt of methylhomatropine. It is a peripherally acting anticholinergic medication that inhibits muscarinic acetylcholine receptors and thus the parasympathetic nervous system. It does not cross the blood–brain barrier. It is used to effectively relieve intestinal spasms and abdominal cramps, without producing the adverse effects of less specific anticholinergics.^[1] It is used, in addition to papaverine, as a component of mild drugs that help "flush" the bile.

Certain preparations of drugs such as hydrocodone are mixed with a small, sub-therapeutic amount of homatropine methylbromide to discourage intentional overdose.^[2]

Contraindications

References

^ "Paratropina (Homatropine Methylbromide)". Archived from the original on 2017-04-29. Retrieved 2016-02-18.
^ "Hydromet (Hydrocodone Bitartrate and Homatropine Methylbromide)". DailyMed. NIH.

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[1] "Paratropina (Homatropine Methylbromide)". Archived from the original on 2017-04-29. Retrieved 2016-02-18.

[2] "Hydromet (Hydrocodone Bitartrate and Homatropine Methylbromide)". DailyMed. NIH.

[1]

[2]

Contraindications

See also

References