Super Conserved Receptor Expressed in Brain

G protein-coupled receptor 85
G protein-coupled receptor 85
Identifiers
Symbol	GPR85
Alt. symbols	SREB2
NCBI gene	54329
HGNC	4536
OMIM	605188
RefSeq	NM_018970
UniProt	P60893
Other data
Locus	Chr. 7 q31
Structures
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Structures	Swiss-model
Domains	InterPro

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Structures	Swiss-model
Domains	InterPro

G protein-coupled receptor 27
G protein-coupled receptor 27
Identifiers
Symbol	GPR27
Alt. symbols	SREB1
NCBI gene	2850
HGNC	4482
OMIM	605187
RefSeq	NM_018971
UniProt	Q9NS67
Other data
Locus	Chr. 3 p21-p14
Structures
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Structures	Swiss-model
Domains	InterPro

G protein-coupled receptor 173

Identifiers

Symbol

GPR173

Alt. symbols

SREB3

Other data

Chr. X p11

Search for
Structures	Swiss-model
Domains	InterPro

The Super Conserved Receptor Expressed in Brain (SREB) family are a group of related G-protein coupled receptors.^[1] Since no endogenous ligands have yet been identified for these receptors, they are classified as orphan receptors. Receptors within the group include SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173).^[2]

References

^ Matsumoto M, Saito T, Takasaki J, Kamohara M, Sugimoto T, Kobayashi M, Tadokoro M, Matsumoto S, Ohishi T, Furuichi K (2000). "An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system". Biochem. Biophys. Res. Commun. 272 (2): 576–82. doi:10.1006/bbrc.2000.2829. PMID 10833454.
^ National Center for Biotechnology Information, , accessed 5 February 2022

External links

IUPHAR GPCR Database - GPR27 (previously SREB1)
IUPHAR GPCR Database - GPR85 (previously SREB2) Archived 2016-03-03 at the Wayback Machine
IUPHAR GPCR Database - GPR173 (previously SREB3) Archived 2016-03-03 at the Wayback Machine
GPR27+protein at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
GPR85+receptor at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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[pmid10833454-1] Matsumoto M, Saito T, Takasaki J, Kamohara M, Sugimoto T, Kobayashi M, Tadokoro M, Matsumoto S, Ohishi T, Furuichi K (2000). "An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system". Biochem. Biophys. Res. Commun. 272 (2): 576–82. doi:10.1006/bbrc.2000.2829. PMID 10833454.

[2] National Center for Biotechnology Information, , accessed 5 February 2022

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