TRAP1

TRAP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4Z1F, 4Z1G, 4Z1H, 4Z1I, 5F3K, 5F5R
Identifiers
Aliases	TRAP1, HSP 75, HSP75, HSP90L, TRAP-1, TNF receptor associated protein 1
External IDs	OMIM: 606219; MGI: 1915265; HomoloGene: 9457; GeneCards: TRAP1; OMA:TRAP1 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	3,717,553 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	3,895,691 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; right uterine tube; ; gastrocnemius muscle; ; triceps brachii muscle; ; glutes; ; right lobe of liver; ; body of pancreas; ; apex of heart; ; skin of leg; ; skin of abdomen;
	Top expressed in
	right kidney; ; Paneth cell; ; muscle of thigh; ; masseter muscle; ; proximal tubule; ; skeletal muscle tissue; ; brown adipose tissue; ; fetal liver hematopoietic progenitor cell; ; human kidney; ; sternocleidomastoid muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; unfolded protein binding; protein binding; tumor necrosis factor receptor binding; ATP binding; protein kinase binding; RNA binding;
Cellular component	membrane; mitochondrial intermembrane space; lipid droplet; nucleoplasm; mitochondrial matrix; mitochondrion; mitochondrial inner membrane; extracellular exosome;
Biological process	response to stress; negative regulation of cellular respiration; protein folding; negative regulation of reactive oxygen species biosynthetic process; translational attenuation; chaperone-mediated protein folding; negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide;
	Sources:Amigo / QuickGO
Orthologs
	10131
	68015
	ENSG00000126602
	ENSMUSG00000005981
	Q12931
	Q9CQN1
	NM_001272049; NM_016292
	NM_026508
	NP_001258978; NP_057376
	NP_080784
	Wikidata
View/Edit Human	View/Edit Mouse

Heat shock protein 75 kDa, mitochondrial is a protein that in humans is encoded by the TRAP1 gene.^[5]^[6]^[7]

Interactions

TRAP1 has been shown to interact with EXT2,^[8] EXT1^[8] and Retinoblastoma protein.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000126602 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000005981 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Felts SJ, Owen BA, Nguyen P, Trepel J, Donner DB, Toft DO (March 2000). "The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties". J Biol Chem. 275 (5): 3305–12. doi:10.1074/jbc.275.5.3305. PMID 10652318.
^ Song HY, Dunbar JD, Zhang YX, Guo D, Donner DB (March 1995). "Identification of a protein with homology to hsp90 that binds the type 1 tumor necrosis factor receptor". J Biol Chem. 270 (8): 3574–81. doi:10.1074/jbc.270.8.3574. PMID 7876093.
^ "Entrez Gene: TRAP1 TNF receptor-associated protein 1".
^ ^a ^b Simmons, A D; Musy M M; Lopes C S; Hwang L Y; Yang Y P; Lovett M (November 1999). "A direct interaction between EXT proteins and glycosyltransferases is defective in hereditary multiple exostoses". Hum. Mol. Genet. 8 (12): 2155–64. doi:10.1093/hmg/8.12.2155. ISSN 0964-6906. PMID 10545594.
^ Chen, C F; Chen Y; Dai K; Chen P L; Riley D J; Lee W H (September 1996). "A new member of the hsp90 family of molecular chaperones interacts with the retinoblastoma protein during mitosis and after heat shock". Mol. Cell. Biol. 16 (9): 4691–9. doi:10.1128/MCB.16.9.4691. ISSN 0270-7306. PMC 231469. PMID 8756626.

External links

TRAP1 human gene location in the UCSC Genome Browser.
TRAP1 human gene details in the UCSC Genome Browser.

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000126602 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000005981 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10652318-5] Felts SJ, Owen BA, Nguyen P, Trepel J, Donner DB, Toft DO (March 2000). "The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties". J Biol Chem. 275 (5): 3305–12. doi:10.1074/jbc.275.5.3305. PMID 10652318.

[pmid7876093-6] Song HY, Dunbar JD, Zhang YX, Guo D, Donner DB (March 1995). "Identification of a protein with homology to hsp90 that binds the type 1 tumor necrosis factor receptor". J Biol Chem. 270 (8): 3574–81. doi:10.1074/jbc.270.8.3574. PMID 7876093.

[entrez-7] "Entrez Gene: TRAP1 TNF receptor-associated protein 1".

[pmid10545594-8] Simmons, A D; Musy M M; Lopes C S; Hwang L Y; Yang Y P; Lovett M (November 1999). "A direct interaction between EXT proteins and glycosyltransferases is defective in hereditary multiple exostoses". Hum. Mol. Genet. 8 (12): 2155–64. doi:10.1093/hmg/8.12.2155. ISSN 0964-6906. PMID 10545594.

[pmid8756626-9] Chen, C F; Chen Y; Dai K; Chen P L; Riley D J; Lee W H (September 1996). "A new member of the hsp90 family of molecular chaperones interacts with the retinoblastoma protein during mitosis and after heat shock". Mol. Cell. Biol. 16 (9): 4691–9. doi:10.1128/MCB.16.9.4691. ISSN 0270-7306. PMC 231469. PMID 8756626.

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Interactions

References

Further reading

External links