UBE1L

UBA7
Identifiers
Aliases	UBA7, D8, UBA1B, UBE1L, UBE2, ubiquitin like modifier activating enzyme 7, UBE7
External IDs	OMIM: 191325; MGI: 1349462; HomoloGene: 2502; GeneCards: UBA7; OMA:UBA7 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	49,813,953 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	107,861,259 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; spleen; ; right uterine tube; ; lymph node; ; appendix; ; duodenum; ; gallbladder; ; right ovary; ; left ovary; ; right lobe of thyroid gland;
	Top expressed in
	granulocyte; ; spleen; ; blood; ; duodenum; ; thymus; ; mesenteric lymph nodes; ; submandibular gland; ; jejunum; ; intestinal villus; ; ileum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	ATP binding; ISG15 activating enzyme activity; nucleotide binding; ubiquitin-like modifier activating enzyme activity; ligase activity; protein binding; ubiquitin-protein transferase activity; ubiquitin activating enzyme activity;
Cellular component	nucleoplasm; cytosol; cytoplasm; nucleus;
Biological process	negative regulation of type I interferon production; ISG15-protein conjugation; protein ubiquitination; modification-dependent protein catabolic process; ubiquitin-dependent protein catabolic process; cellular response to DNA damage stimulus; protein modification by small protein conjugation;
	Sources:Amigo / QuickGO
Orthologs
	7318
	74153
	ENSG00000182179
	ENSMUSG00000032596
	P41226
	n/a
	NM_003335
	NM_023738
	NP_003326
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin-like modifier-activating enzyme 7 is a protein that in humans is encoded by the UBA7 gene.^[5]^[6]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000182179 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032596 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kok K, Hofstra R, Pilz A, van den Berg A, Terpstra P, Buys CH, Carritt B (Aug 1993). "A gene in the chromosomal region 3p21 with greatly reduced expression in lung cancer is similar to the gene for ubiquitin-activating enzyme". Proc Natl Acad Sci U S A. 90 (13): 6071–5. Bibcode:1993PNAS...90.6071K. doi:10.1073/pnas.90.13.6071. PMC 46869. PMID 8327486.
^ ^a ^b "Entrez Gene: UBE1L ubiquitin-activating enzyme E1-like".

Carritt B, Kok K, van den Berg A, et al. (1992). "A gene from human chromosome region 3p21 with reduced expression in small cell lung cancer". Cancer Res. 52 (6): 1536–41. PMID 1311632.
Kok K, Van den Berg A, Veldhuis PM, et al. (1995). "The genomic structure of the human UBE1L gene". Gene Expr. 4 (3): 163–75. PMC 6134375. PMID 7734949.
McLaughlin PM, Helfrich W, Kok K, et al. (2000). "The ubiquitin-activating enzyme E1-like protein in lung cancer cell lines". Int. J. Cancer. 85 (6): 871–6. doi:10.1002/(SICI)1097-0215(20000315)85:6<871::AID-IJC22>3.0.CO;2-O. PMID 10709110.
Yuan W, Krug RM (2001). "Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein". EMBO J. 20 (3): 362–71. doi:10.1093/emboj/20.3.362. PMC 133459. PMID 11157743.
Kitareewan S, Pitha-Rowe I, Sekula D, et al. (2002). "UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemia". Proc. Natl. Acad. Sci. U.S.A. 99 (6): 3806–11. Bibcode:2002PNAS...99.3806K. doi:10.1073/pnas.052011299. PMC 122605. PMID 11891284.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Pitha-Rowe I, Hassel BA, Dmitrovsky E (2004). "Involvement of UBE1L in ISG15 conjugation during retinoid-induced differentiation of acute promyelocytic leukemia". J. Biol. Chem. 279 (18): 18178–87. doi:10.1074/jbc.M309259200. PMID 14976209.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Lenschow DJ, Giannakopoulos NV, Gunn LJ, et al. (2006). "Identification of interferon-stimulated gene 15 as an antiviral molecule during Sindbis virus infection in vivo". J. Virol. 79 (22): 13974–83. doi:10.1128/JVI.79.22.13974-13983.2005. PMC 1280211. PMID 16254333.
Takeuchi T, Iwahara S, Saeki Y, et al. (2005). "Link between the Ubiquitin Conjugation System and the ISG15 Conjugation System: ISG15 Conjugation to the UbcH6 Ubiquitin E2 Enzyme". J. Biochem. 138 (6): 711–9. doi:10.1093/jb/mvi172. PMID 16428300.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000182179 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032596 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8327486-5] Kok K, Hofstra R, Pilz A, van den Berg A, Terpstra P, Buys CH, Carritt B (Aug 1993). "A gene in the chromosomal region 3p21 with greatly reduced expression in lung cancer is similar to the gene for ubiquitin-activating enzyme". Proc Natl Acad Sci U S A. 90 (13): 6071–5. Bibcode:1993PNAS...90.6071K. doi:10.1073/pnas.90.13.6071. PMC 46869. PMID 8327486.

[entrez-6] "Entrez Gene: UBE1L ubiquitin-activating enzyme E1-like".

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References

Further reading