POLD4

POLD4
Identifiers
Aliases	POLD4, POLDS, p12, polymerase (DNA) delta 4, accessory subunit, DNA polymerase delta 4, accessory subunit
External IDs	OMIM: 611525 MGI: 1916995 HomoloGene: 10909 GeneCards: POLD4
Gene location (Human)
Chr.	Chromosome 11 (human)
End	67,356,972 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	4,283,688 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; duodenum; ; appendix; ; lymph node; ; blood; ; left coronary artery; ; right coronary artery; ; spleen; ; ascending aorta; ; body of pancreas;
	Top expressed in
	spleen; ; white adipose tissue; ; urinary bladder; ; adrenal gland; ; bone marrow; ; pancreas; ; islet of Langerhans; ; lip; ; esophagus; ; jejunum;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; DNA-directed DNA polymerase activity;
Cellular component	delta DNA polymerase complex; nucleoplasm; nucleolus; mitochondrion; cytosol; nucleus;
Biological process	DNA-dependent DNA replication; nucleotide-excision repair, DNA gap filling; DNA synthesis involved in DNA repair; translesion synthesis; transcription-coupled nucleotide-excision repair; nucleotide-excision repair, DNA incision; telomere maintenance; nucleotide-excision repair, DNA incision, 5'-to lesion; DNA repair; cellular response to DNA damage stimulus; telomere maintenance via semi-conservative replication; DNA replication; DNA mismatch repair;
	Sources:Amigo / QuickGO
Orthologs
	57804
	69745
	ENSG00000175482
	ENSMUSG00000024854
	Q9HCU8
	Q9CWP8
	NM_001256870; NM_021173
	NM_027196
	NP_001243799; NP_066996
	NP_081472
	Wikidata
View/Edit Human	View/Edit Mouse

DNA polymerase delta subunit 4, also known as DNA polymerase delta subunit p12, is a protein that in humans is encoded by the POLD4 gene.^[5] It is a component of the DNA polymerase delta complex.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000175482 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024854 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: polymerase (DNA-directed)".

Xie B, Mazloum N, Liu L, et al. (2002). "Reconstitution and characterization of the human DNA polymerase delta four-subunit holoenzyme". Biochemistry. 41 (44): 13133–42. doi:10.1021/bi0262707. PMID 12403614.
Selak N, Bachrati CZ, Shevelev I, et al. (2008). "The Bloom's syndrome helicase (BLM) interacts physically and functionally with p12, the smallest subunit of human DNA polymerase delta". Nucleic Acids Res. 36 (16): 5166–79. doi:10.1093/nar/gkn498. PMC 2532730. PMID 18682526.
Bae SH, Bae KH, Kim JA, Seo YS (2001). "RPA governs endonuclease switching during processing of Okazaki fragments in eukaryotes". Nature. 412 (6845): 456–61. doi:10.1038/35086609. PMID 11473323. S2CID 4337704.
Matsumoto Y, Kim K, Hurwitz J, et al. (1999). "Reconstitution of proliferating cell nuclear antigen-dependent repair of apurinic/apyrimidinic sites with purified human proteins". J. Biol. Chem. 274 (47): 33703–8. doi:10.1074/jbc.274.47.33703. PMID 10559261.
Liu G, Warbrick E (2006). "The p66 and p12 subunits of DNA polymerase delta are modified by ubiquitin and ubiquitin-like proteins". Biochem. Biophys. Res. Commun. 349 (1): 360–6. doi:10.1016/j.bbrc.2006.08.049. PMID 16934752.
Tsurimoto T, Shinozaki A, Yano M, et al. (2005). "Human Werner helicase interacting protein 1 (WRNIP1) functions as a novel modulator for DNA polymerase delta". Genes Cells. 10 (1): 13–22. doi:10.1111/j.1365-2443.2004.00812.x. PMID 15670210. S2CID 24977510.
Wood RD, Shivji MK (1997). "Which DNA polymerases are used for DNA-repair in eukaryotes?". Carcinogenesis. 18 (4): 605–10. doi:10.1093/carcin/18.4.605. PMID 9111189.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Huang QM, Akashi T, Masuda Y, et al. (2010). "Roles of POLD4, smallest subunit of DNA polymerase delta, in nuclear structures and genomic stability of human cells". Biochem. Biophys. Res. Commun. 391 (1): 542–6. doi:10.1016/j.bbrc.2009.11.094. PMID 19931513.
Li H, Xie B, Zhou Y, et al. (2006). "Functional roles of p12, the fourth subunit of human DNA polymerase delta". J. Biol. Chem. 281 (21): 14748–55. doi:10.1074/jbc.M600322200. PMID 16510448.
Liu L, Mo J, Rodriguez-Belmonte EM, Lee MY (2000). "Identification of a fourth subunit of mammalian DNA polymerase delta". J. Biol. Chem. 275 (25): 18739–44. doi:10.1074/jbc.M001217200. PMID 10751307.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000175482 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024854 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: polymerase (DNA-directed)".

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References

Further reading