A | B | C | D | E | F | G | H | CH | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 0 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9
DNA replication gene dnaC | |||||||
---|---|---|---|---|---|---|---|
Identifiers | |||||||
Organism | |||||||
Symbol | dnaC | ||||||
Entrez | 948864 | ||||||
RefSeq (Prot) | NP_418781.1 | ||||||
UniProt | P0AEF0 | ||||||
Other data | |||||||
EC number | 2.7.7.7 | ||||||
Chromosome | genome: 4.6 - 4.6 Mb | ||||||
|
dnaC is a loading factor that complexes with the C-terminus of helicase dnaB and inhibits it from unwinding the dsDNA at a replication fork.[1] A dnaB and dnaC associate near the dnaA bound origin for each of the ssDNA.[1] One dnaB-dnaC complex is oriented in the opposite direction to the other dnaB-dnaC complex due to the antiparallel nature of DNA. Because they are oriented in opposite directions, one dnaB-dnaC complex will complex with dnaA from the N-terminus of dnaB whereas the other dnaB-dnaC complex will complex with dnaA from the dnaC. After the assembly of dnaG onto the N-terminus of dnaB, dnaC is released and dnaB will be allowed to begin unwinding dsDNA to make room for DNA polymerase III to begin synthesizing the daughter strands.[1]
This interaction of dnaC with dnaB requires the hydrolysis of ATP.[2]
References
- ^ a b c Slonczewski JL, Foster JW, Gillen KM (2009). Microbiology: an evolving science (1st ed.). New York: W.W. Norton & Co. ISBN 978-0-393-97857-5.
- ^ Kobori JA, Kornberg A (November 1982). "The Escherichia coli dnaC gene product. III. Properties of the dnaB-dnaC protein complex". The Journal of Biological Chemistry. 257 (22): 13770–5. PMID 6292205. Archived from the original on 2007-09-29. Retrieved 2007-08-20.
External links
- DnaC+protein,+E+coli at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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