NEFA (drug)

NEFA
Identifiers
	IUPAC name (4aR,9aS)-N-Ethyl-4,4a,9,9a-tetrahydro-1H-fluoren-4a-amine;
CAS Number	127140-88-9 ;
PubChem CID	57426056;
UNII	JMF9RU2BLC;
Chemical and physical data
Formula	C15H19N
Molar mass	213.324 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCN12CC=CC1CC3=CC=CC=C23;
	InChI InChI=1S/C15H19N/c1-2-16-15-10-6-5-8-13(15)11-12-7-3-4-9-14(12)15/h3-7,9,13,16H,2,8,10-11H2,1H3/t13-,15+/m0/s1; Key:DRCWOKJLSQUJPZ-DZGCQCFKSA-N;
	(verify)

NEFA is a moderate affinity NMDA antagonist (IC₅₀ = 0.51 μM). It is a structural analog of phencyclidine.^[1] It was first synthesized by a team at Parke-Davis in the late 1950s.^[2]

References

Identifiers

IUPAC name (4aR,9aS)-N-Ethyl-4,4a,9,9a-tetrahydro-1H-fluoren-4a-amine
CAS Number	127140-88-9^Y
PubChem CID	57426056
UNII	JMF9RU2BLC
Chemical and physical data
Formula	C₁₅H₁₉N
Molar mass	213.324 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CCN12CC=CC1CC3=CC=CC=C23
InChI InChI=1S/C15H19N/c1-2-16-15-10-6-5-8-13(15)11-12-7-3-4-9-14(12)15/h3-7,9,13,16H,2,8,10-11H2,1H3/t13-,15+/m0/s1 Key:DRCWOKJLSQUJPZ-DZGCQCFKSA-N
(verify)