JWH-372

Legal status
Legal status	CA: Schedule II UK: Class B
Identifiers
IUPAC name naphthalen-1-yl-2-(trifluoromethyl)phenylpyrrol-3-ylmethanone
CAS Number	914458-28-9 Y
PubChem CID	44418325
ChemSpider	23277903 Y
CompTox Dashboard (EPA)	DTXSID401337000
Chemical and physical data
Formula	C27H24F3NO
Molar mass	435.490 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCCCCN1C=C(C=C1C2=CC=CC=C2C(F)(F)F)C(=O)C3=CC=CC4=CC=CC=C43
InChI InChI=1S/C27H24F3NO/c1-2-3-8-16-31-18-20(17-25(31)23-13-6-7-15-24(23)27(28,29)30)26(32)22-14-9-11-19-10-4-5-12-21(19)22/h4-7,9-15,17-18H,2-3,8,16H2,1H3 Y Key:CYPUIQJYGVOHMM-UHFFFAOYSA-N Y

JWH-372 (naphthalen-1-yl-1-pentyl-5-2-(trifluoromethyl)phenylpyrrol-3-ylmethanone) is a synthetic cannabinoid from the naphthoylpyrrole family which acts as a potent and selective agonist of the CB₂ receptor. JWH-372 binds approximately 9 times stronger to the CB₂ receptor (K_i = 8.2 ± 0.2nM) than the CB₁ receptor (K_i = 77 ± 2nM). The selectivity of JWH-372 for the CB₂ receptor is likely due to the electron-withdrawing character of the trifluoromethyl group rather than steric effects, as the o-methyl compound JWH-370 was only mildly selective for the CB₂ receptor (CB₁ K_i = 5.6 ± 0.4nM, CB₂ K_i = 4.0 ± 0.5nM). ^[1]

Legalityedit

In the United States JWH-372 is not federally scheduled, although some states have passed legislation banning the sale, possession, and manufacture of JWH-372.^[2][3][4][5]

In Canada, JWH-372 and other naphthoylpyrrole-based cannabinoids are Schedule II controlled substances under the Controlled Drugs and Substances Act.^{[citation needed]}

In the United Kingdom, JWH-372 and other naphthoylpyrrole-based cannabinoids are considered Class B drugs under the Misuse of Drugs Act 1971.^{[citation needed]}

See alsoedit

• List of JWH cannabinoids
• Synthetic cannabinoid

Referencesedit

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