CD177

CD177
Identifiers
Aliases	CD177, HNA-2a, HNA2A, NB1, NB1 GP, PRV-1, PRV1, CD177 molecule
External IDs	OMIM: 162860; MGI: 1916141; HomoloGene: 49628; GeneCards: CD177; OMA:CD177 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	43,363,172 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	24,459,736 bp
RNA expression pattern
	Top expressed in
	rectum; ; mucosa of colon; ; mucosa of sigmoid colon; ; mucosa of transverse colon; ; bone marrow; ; bone marrow cells; ; spleen; ; trabecular bone; ; prostate; ; blood;
	Top expressed in
	secondary oocyte; ; large intestine; ; colon; ; left colon; ; bone marrow; ; trachea; ; Paneth cell; ; blood; ; body of femur; ; morula;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; protease binding; integrin binding; calcium-dependent protein binding;
Cellular component	anchored component of membrane; extracellular exosome; membrane; specific granule membrane; plasma membrane; secretory granule membrane; plasma membrane raft; tertiary granule membrane; extracellular region; lamellipodium; cell projection; membrane raft;
Biological process	blood coagulation; leukocyte migration; neutrophil degranulation; cell adhesion; leukocyte cell-cell adhesion; regulation of endocytosis; positive regulation of superoxide anion generation; protein localization to cell surface; positive regulation of neutrophil degranulation; cell-cell junction maintenance; neutrophil extravasation; cell-cell adhesion via plasma-membrane adhesion molecules; neutrophil migration; regulation of integrin-mediated signaling pathway; immune system process; innate immune response;
	Sources:Amigo / QuickGO
Orthologs
	57126
	68891
	ENSG00000204936
	ENSMUSG00000052212
	Q8N6Q3
	Q8R2S8
	NM_020406
	NM_026862
	NP_065139
	NP_081138
	Wikidata
View/Edit Human	View/Edit Mouse

CD177 antigen is a protein that in humans is encoded by the CD177 gene.^[5]^[6]^[7]

NB1, a glycosyl-phosphatidylinositol (GPI)-linked N-glycosylated cell surface glycoprotein, was first described in a case of neonatal alloimmune neutropenia (Lalezari et al., 1971). ^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000204936 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000052212 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Temerinac S, Klippel S, Strunck E, Roder S, Lubbert M, Lange W, Azemar M, Meinhardt G, Schaefer HE, Pahl HL (May 2000). "Cloning of PRV-1, a novel member of the uPAR receptor superfamily, which is overexpressed in polycythemia rubra vera". Blood. 95 (8): 2569–76. doi:10.1182/blood.V95.8.2569. PMID 10753836.
^ Lalezari P, Murphy GB, Allen FH Jr (Jun 1971). "NB1, a new neutrophil-specific antigen involved in the pathogenesis of neonatal neutropenia". J Clin Invest. 50 (5): 1108–15. doi:10.1172/JCI106582. PMC 292033. PMID 5552408.
^ ^a ^b "Entrez Gene: CD177 CD177 molecule".

Stroncek D (2003). "Neutrophil-specific antigen HNA-2a (NB1, CD177): serology, biochemistry, and molecular biology". Vox Sang. 83 (Suppl 1): 359–61. doi:10.1111/j.1423-0410.2002.tb05334.x. PMID 12617169. S2CID 36683379.
Pahl HL (2003). "PRV-1 mRNA expression and other molecular markers in polycythemia rubra vera". Curr. Hematol. Rep. 2 (3): 231–6. PMID 12901344.
Kralovics R, Skoda RC (2005). "Molecular pathogenesis of Philadelphia chromosome negative myeloproliferative disorders". Blood Rev. 19 (1): 1–13. doi:10.1016/j.blre.2004.02.002. PMID 15572213.
Goldschmeding R, van Dalen CM, Faber N, et al. (1992). "Further characterization of the NB 1 antigen as a variably expressed 56-62 kD GPI-linked glycoprotein of plasma membranes and specific granules of neutrophils". Br. J. Haematol. 81 (3): 336–45. doi:10.1111/j.1365-2141.1992.tb08237.x. PMID 1382544. S2CID 11604830.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Stroncek DF, Herr GP, Plachta LB (1994). "Neutrophil-specific antigen NB1 inhibits neutrophil-endothelial cell interactions". J. Lab. Clin. Med. 123 (2): 247–55. PMID 8301201.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Kissel K, Santoso S, Hofmann C, et al. (2001). "Molecular basis of the neutrophil glycoprotein NB1 (CD177) involved in the pathogenesis of immune neutropenias and transfusion reactions". Eur. J. Immunol. 31 (5): 1301–9. doi:10.1002/1521-4141(200105)31:5<1301::AID-IMMU1301>3.0.CO;2-J. PMID 11465086. S2CID 33769082.
Bettinotti MP, Olsen A, Stroncek D (2002). "The use of bioinformatics to identify the genomic structure of the gene that encodes neutrophil antigen NB1, CD177". Clin. Immunol. 102 (2): 138–44. doi:10.1006/clim.2001.5154. PMID 11846455.
Kissel K, Scheffler S, Kerowgan M, Bux J (2002). "Molecular basis of NB1 (HNA-2a, CD177) deficiency". Blood. 99 (11): 4231–3. doi:10.1182/blood.V99.11.4231. PMID 12010833.
Klippel S, Strunck E, Busse CE, et al. (2002). "Biochemical characterization of PRV-1, a novel hematopoietic cell surface receptor, which is overexpressed in polycythemia rubra vera". Blood. 100 (7): 2441–8. doi:10.1182/blood-2002-03-0949. PMID 12239154.
Teofili L, Martini M, Luongo M, et al. (2002). "Overexpression of the polycythemia rubra vera-1 gene in essential thrombocythemia". J. Clin. Oncol. 20 (20): 4249–54. doi:10.1200/JCO.2002.11.507. PMID 12377969.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Najfeld V, Fuchs S, Merando P, et al. (2003). "Fluorescence in situ hybridization analysis of the PRV-1 gene in polycythemia vera: implications for its role in diagnosis and pathogenesis". Exp. Hematol. 31 (2): 118–21. doi:10.1016/S0301-472X(02)01032-9. PMID 12591276.
Wolff J, Brendel C, Fink L, et al. (2003). "Lack of NB1 GP (CD177/HNA-2a) gene transcription in NB1 GP- neutrophils from NB1 GP-expressing individuals and association of low expression with NB1 gene polymorphisms". Blood. 102 (2): 731–3. doi:10.1182/blood-2002-09-2831. PMID 12623849.
Johansson P, Andréasson B, Safai-Kutti S, et al. (2003). "The presence of a significant association between elevated PRV-1 mRNA expression and low plasma erythropoietin concentration in essential thrombocythaemia". Eur. J. Haematol. 70 (6): 358–62. doi:10.1034/j.1600-0609.2003.00079.x. PMID 12756017. S2CID 13222207.

External links

CD177+Antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human CD177 genome location and CD177 gene details page in the UCSC Genome Browser.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000204936 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000052212 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10753836-5] Temerinac S, Klippel S, Strunck E, Roder S, Lubbert M, Lange W, Azemar M, Meinhardt G, Schaefer HE, Pahl HL (May 2000). "Cloning of PRV-1, a novel member of the uPAR receptor superfamily, which is overexpressed in polycythemia rubra vera". Blood. 95 (8): 2569–76. doi:10.1182/blood.V95.8.2569. PMID 10753836.

[pmid5552408-6] Lalezari P, Murphy GB, Allen FH Jr (Jun 1971). "NB1, a new neutrophil-specific antigen involved in the pathogenesis of neonatal neutropenia". J Clin Invest. 50 (5): 1108–15. doi:10.1172/JCI106582. PMC 292033. PMID 5552408.

[entrez-7] "Entrez Gene: CD177 CD177 molecule".

[1]

[2]

[3]

[4]

[5]

[6]

[7]

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

See also

References

Further reading

External links