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The Nobel Prize in Physiology or Medicine (Swedish: Nobelpriset i fysiologi eller medicin) is awarded annually by the Swedish Karolinska Institute to scientists in the various fields of physiology or medicine. It is one of the five Nobel Prizes established by the 1895 will of Alfred Nobel (who died in 1896), awarded for outstanding contributions in chemistry, physics, literature, peace, and physiology or medicine.[1] As dictated by Nobel's will, the award is administered by the Nobel Foundation and awarded by a committee that consists of five members and an executive secretary elected by the Karolinska Institute.[2][3] While commonly referred to as the Nobel Prize in Medicine, Nobel specifically stated that the prize be awarded for "physiology or medicine" in his will. Because of this, the prize can be awarded in a broader range of fields.[3] The first Nobel Prize in Physiology or Medicine was awarded in 1901 to Emil Adolf von Behring, of Germany. Each recipient receives a medal, a diploma and a monetary award that has varied throughout the years.[4] In 1901, von Behring received 150,782 SEK, which was equal to 7,731,004 SEK in December 2008. The award is presented in Stockholm at an annual ceremony on 10 December, the anniversary of Nobel's death.[5]
Laureates have won the Nobel Prize in a wide range of fields that relate to physiology or medicine. As of 2009, 8 Prizes have been awarded for contributions in the field of signal transduction by G proteins and second messengers, 13 have been awarded for contributions in the field of neurobiology and 13 have been awarded for contributions in intermediary metabolism.[3] In 1939 Gerhard Domagk, a German, was not allowed by his government to accept the prize. He later received a medal and diploma, but not the money.[6] As of 2021, the prize has been awarded to 224 individuals, twelve of them were women (Gerty Cori being the first to be awarded in 1947).[7]
There have been nine years in which the Nobel Prize in Physiology or Medicine was not awarded (1915–1918, 1921, 1925, 1940–1942). There were also five years for which the Nobel Prize in Physiology or Medicine was delayed for one year. The Prize was not awarded in 1914, as the Nobel Committee for Physiology or Medicine decided that none of that year's nominations met the necessary criteria, but was awarded to Robert Bárány in 1915 and counted as the 1914 prize.[8] This precedent was followed for the 1922 prize awarded to Archibald Hill and Otto Fritz Meyerhof in 1923,[9] the 1926 prize awarded to Johannes Fibiger in 1927,[10] the 1938 prize awarded to Corneille Heymans in 1939,[11] and the 1943 prize awarded to Henrik Dam and Edward Adelbert Doisy in 1944.[12]
Laureates
Year | Image | Laureate | Country | Rationale | Ref |
---|---|---|---|---|---|
1901 | Emil von Behring (1854–1917) | Germany | "for his work on serum therapy, especially its application against diphtheria, by which he has opened a new road in the domain of medical science and thereby placed in the hands of the physician a victorious weapon against illness and deaths" | [13] | |
1902 | Sir Ronald Ross (1857–1932) | United Kingdom | "for his work on malaria, by which he has shown how it enters the organism and thereby has laid the foundation for successful research on this disease and methods of combating it" | [14] | |
1903 | Niels Ryberg Finsen (1860–1904) | Denmark | " his contribution to the treatment of diseases, especially lupus vulgaris, with concentrated light radiation, whereby he has opened a new avenue for medical science" | [15] | |
1904 | Ivan Pavlov (1849–1936) | Russia | "in recognition of his work on the physiology of digestion, through which knowledge on vital aspects of the subject has been transformed and enlarged" | [16] | |
1905 | Robert Koch (1843–1910) | Germany | "for his investigations and discoveries in relation to tuberculosis" | [17] | |
1906 | Camillo Golgi (1843–1926) | Italy | "in recognition of their work on the structure of the nervous system" | [18] | |
Santiago Ramón y Cajal (1852–1934) | Spain | ||||
1907 | Charles Louis Alphonse Laveran (1845–1922) | France | "in recognition of his work on the role played by protozoa in causing diseases" | [19] | |
1908 | Élie Metchnikoff (1845–1916) | Russia | "in recognition of their work on immunity" | [20] | |
Paul Ehrlich (1854–1915) | Germany | ||||
1909 | Emil Theodor Kocher (1841–1917) | Switzerland | "for his work on the physiology, pathology and surgery of the thyroid gland" | [21] | |
1910 | Albrecht Kossel (1853–1927) | Germany | "in recognition of the contributions to our knowledge of cell chemistry made through his work on proteins, including the nucleic substances" | [22] | |
1911 | Allvar Gullstrand (1862–1930) | Sweden | "for his work on the dioptrics of the eye" | [23] | |
1912 | Alexis Carrel (1873–1944) | France | " his work on vascular suture and the transplantation of blood vessels and organs" | [24] | |
1913 | Charles Richet (1850–1935) | France | " his work on anaphylaxis" | [25] | |
1914 | Robert Bárány (1876–1936) | Austria-Hungary | "for his work on the physiology and pathology of the vestibular apparatus" | [8] | |
1915 | Not awarded | ||||
1916 | |||||
1917 | |||||
1918 | |||||
1919 | Jules Bordet (1870–1961) | Belgium | "for his discoveries relating to immunity" | [26] | |
1920 | August Krogh (1874–1949) | Denmark | "for his discovery of the capillary motor regulating mechanism" | [27] | |
1921 | Not awarded | ||||
1922 | Archibald Hill (1886–1977) | United Kingdom | "for his discovery relating to the production of heat in the muscle" | [9] | |
Otto Fritz Meyerhof (1884–1951) | Germany | "for his discovery of the fixed relationship between the consumption of oxygen and the metabolism of lactic acid in the muscle" | [9] | ||
1923 | Sir Frederick Banting (1891–1941) | Canada | "for the discovery of insulin" | [28] | |
John Macleod (1876–1935) | United Kingdom | ||||
1924 | Willem Einthoven (1860–1927) | Netherlands | "for the discovery of the mechanism of the electrocardiogram" | [29] | |
1925 | Not awarded | ||||
1926 | Johannes Fibiger (1867–1928) | Denmark | "for his discovery of the Spiroptera carcinoma" | [10] | |
1927 | Julius Wagner-Jauregg (1857–1940) | Austria | "for his discovery of the therapeutic value of malaria inoculation in the treatment of dementia paralytica" | [30] | |
1928 | Charles Nicolle (1866–1936) | France | "for his work on typhus" | [31] | |
1929 | Christiaan Eijkman (1868–1930) | Netherlands | "for his discovery of the antineuritic vitamin" | [32] | |
Sir Frederick Gowland Hopkins (1861–1947) | United Kingdom | "for his discovery of the growth-stimulating vitamins" | [32] | ||
1930 | Karl Landsteiner (1868–1943) | Austria | "for his discovery of human blood groups" | [33] | |
1931 | Otto Heinrich Warburg (1883–1970) | Germany | "for his discovery of the nature and mode of action of the respiratory enzyme" | [34] | |
1932 | Sir Charles Scott Sherrington (1857–1952) | United Kingdom | "for their discoveries regarding the functions of neurons" | [35] | |
Edgar Adrian (1889–1977) | |||||
1933 | Thomas Hunt Morgan (1866–1945) | United States | "for his discoveries concerning the role played by the chromosome in heredity" | [36] | |
1934 | George Whipple (1878–1976) | United States | "for their discoveries concerning liver therapy in cases of anaemia" | [37] | |
George Minot (1885–1950) | |||||
William P. Murphy (1892–1987) | |||||
1936 | Sir Henry Hallett Dale (1875–1968) | United Kingdom | "for their discoveries relating to chemical transmission of nerve impulses" | [38] | |
Otto Loewi (1873–1961) | Austria | ||||
1937 | Albert Szent-Györgyi (1893–1986) | Hungary | "for his discoveries in connection with the biological combustion processes, with special reference to vitamin C and the catalysis of fumaric acid" | [39] | |
1938 | Corneille Heymans (1892–1968) | Belgium | "for the discovery of the role played by the sinus and aortic mechanisms in the regulation of respiration" | [11] | |
1939 | Gerhard Domagk (1895–1964) | Germany | "for the discovery of the antibacterial effects of prontosil" | [40] | |
1940 | Not awarded | ||||
1941 | |||||
1942 | |||||
1943 | Henrik Dam (1895–1976) | Denmark | "for his discovery of vitamin K" | [12] | |
Edward Adelbert Doisy (1893–1986) | United States | "for his discovery of the chemical nature of vitamin K" | [12] | ||
1944 | Joseph Erlanger (1874–1965) | United States | "for their discoveries relating to the highly differentiated functions of single nerve fibres" | [41] | |
Herbert Spencer Gasser (1888–1963) | |||||
1945 | Sir Alexander Fleming (1881–1955) | United Kingdom | "for the discovery of penicillin and its curative effect in various infectious diseases" | [42] | |
Sir Ernst Boris Chain (1906–1979) | |||||
Howard Walter Florey (1898–1968) | Australia | ||||
1946 | Hermann Joseph Muller (1890–1967) | United States | "for the discovery of the production of mutations by means of X-ray irradiation" | [43] | |
1947 | Carl Ferdinand Cori (1896–1984) | United States | "for their discovery of the course of the catalytic conversion of glycogen" | [44] | |
Gerty Theresa Cori, née Radnitz (1896–1957) | |||||
Bernardo Alberto Houssay (1887–1971) | Argentina | "for his discovery of the part played by the hormone of the anterior pituitary lobe in the metabolism of sugar" | [44] | ||
1948 | Paul Hermann Müller (1899–1965) | Switzerland | "for his discovery of the high efficiency of DDT as a contact poison against several arthropods" | [45] | |
1949 | Walter Rudolf Hess (1881–1973) | Switzerland | "for his discovery of the functional organization of the interbrain as a coordinator of the activities of the internal organs" | [46] | |
António Caetano Egas Moniz (1874–1955) | Portugal | "for his discovery of the therapeutic value of leucotomy (lobotomy) in certain psychoses" | [46] | ||
1950 | Philip Showalter Hench (1896–1965) | United States | "for their discoveries relating to the hormones of the adrenal cortex, their structure and biological effects" | [47] | |
Edward Calvin Kendall (1886–1972) | |||||
Tadeusz Reichstein (1897–1996) | Switzerland | ||||
1951 | Max Theiler (1899–1972) | South Africa United States |
"for his discoveries concerning yellow fever and how to combat it" | [48] | |
1952 | Selman Abraham Waksman (1888–1973) | United States | "for his discovery of streptomycin, the first antibiotic effective against tuberculosis" | [49] | |
1953 | Sir Hans Adolf Krebs (1900–1981) | United Kingdom | "for his discovery of the citric acid cycle" | [50] | |
Fritz Albert Lipmann (1899–1986) | United States | "for his discovery of co-enzyme A and its importance for intermediary metabolism" | [50] | ||
1954 | John Franklin Enders (1897–1985) | United States | "for their discovery of the ability of poliomyelitis viruses to grow in cultures of various types of tissue" | [51] | |
Frederick Chapman Robbins (1916–2003) | |||||
Thomas Huckle Weller (1915–2008) | |||||
1955 | Axel Hugo Theodor Theorell (1903–1982) | Sweden | "for his discoveries concerning the nature and mode of action of oxidation enzymes" | [52] | |
1956 |
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