IGFBP6

IGFBP6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1RMJ
Identifiers
Aliases	IGFBP6, IBP6, insulin like growth factor binding protein 6
External IDs	OMIM: 146735 MGI: 96441 HomoloGene: 1641 GeneCards: IGFBP6
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	102,057,946 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; tibial nerve; ; gastric mucosa; ; canal of the cervix; ; left uterine tube; ; right coronary artery; ; thoracic aorta; ; ascending aorta; ; trigeminal ganglion; ; left coronary artery;
	Top expressed in
	ankle; ; uterus; ; right lung; ; right lung lobe; ; ankle joint; ; cervix; ; left lung; ; lip; ; white adipose tissue; ; esophagus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	insulin-like growth factor binding; signaling receptor binding; growth factor binding; insulin-like growth factor I binding; insulin-like growth factor II binding; fibronectin binding;
Cellular component	cytoplasm; Golgi apparatus; extracellular region; extracellular space; insulin-like growth factor binary complex;
Biological process	regulation of insulin-like growth factor receptor signaling pathway; negative regulation of canonical Wnt signaling pathway; regulation of cell growth; signal transduction; negative regulation of cell population proliferation;
	Sources:Amigo / QuickGO
Orthologs
	3489
	16012
	n/a
	ENSMUSG00000023046
	P24592
	P47880
	NM_002178
	NM_008344
	NP_002169
	NP_032370
	Wikidata
View/Edit Human	View/Edit Mouse

Insulin-like growth factor-binding protein 6 (IGFBP-6) is a protein that in humans is encoded by the IGFBP6 gene.^[4]^[5]^[6]

References

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023046 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kiefer MC, Ioh RS, Bauer DM, Zapf J (May 1991). "Molecular cloning of a new human insulin-like growth factor binding protein". Biochem Biophys Res Commun. 176 (1): 219–25. doi:10.1016/0006-291X(91)90912-Q. PMID 1850258.
^ Ehrenborg E, Zazzi H, Lagercrantz S, Granqvist M, Hillerbrand U, Allander SV, Larsson C, Luthman H (May 1999). "Characterization and chromosomal localization of the human insulin-like growth factor-binding protein 6 gene". Mamm Genome. 10 (4): 376–80. doi:10.1007/s003359901005. PMID 10087296. S2CID 21499958.
^ "Entrez Gene: IGFBP6 insulin-like growth factor binding protein 6".

Wood AW, Duan C, Bern HA (2005). "Insulin-like growth factor signaling in fish". Int. Rev. Cytol. International Review of Cytology. 243: 215–85. doi:10.1016/S0074-7696(05)43004-1. ISBN 9780123646477. PMID 15797461.
Zapf J, Kiefer M, Merryweather J, et al. (1990). "Isolation from adult human serum of four insulin-like growth factor (IGF) binding proteins and molecular cloning of one of them that is increased by IGF I administration and in extrapancreatic tumor hypoglycemia". J. Biol. Chem. 265 (25): 14892–8. doi:10.1016/S0021-9258(18)77200-1. PMID 1697583.
Kiefer MC, Masiarz FR, Bauer DM, Zapf J (1991). "Identification and molecular cloning of two new 30-kDa insulin-like growth factor binding proteins isolated from adult human serum". J. Biol. Chem. 266 (14): 9043–9. doi:10.1016/S0021-9258(18)31549-7. PMID 1709161.
Shimasaki S, Gao L, Shimonaka M, Ling N (1991). "Isolation and molecular cloning of insulin-like growth factor-binding protein-6". Mol. Endocrinol. 5 (7): 938–48. doi:10.1210/mend-5-7-938. PMID 1719383.
Andress DL, Birnbaum RS (1991). "A novel human insulin-like growth factor binding protein secreted by osteoblast-like cells". Biochem. Biophys. Res. Commun. 176 (1): 213–8. doi:10.1016/0006-291X(91)90911-P. PMID 1850257.
Martin JL, Willetts KE, Baxter RC (1990). "Purification and properties of a novel insulin-like growth factor-II binding protein from transformed human fibroblasts". J. Biol. Chem. 265 (7): 4124–30. doi:10.1016/S0021-9258(19)39711-X. PMID 2154495.
Roghani M, Hossenlopp P, Lepage P, et al. (1989). "Isolation from human cerebrospinal fluid of a new insulin-like growth factor-binding protein with a selective affinity for IGF-II". FEBS Lett. 255 (2): 253–8. doi:10.1016/0014-5793(89)81101-9. PMID 2551732. S2CID 22982971.
Ilvesmäki V, Blum WF, Voutilainen R (1994). "Insulin-like growth factor binding proteins in the human adrenal gland". Mol. Cell. Endocrinol. 97 (1–2): 71–9. doi:10.1016/0303-7207(93)90212-3. PMID 7511544. S2CID 22503525.
Kato M, Ishizaki A, Hellman U, et al. (1995). "A human keratinocyte cell line produces two autocrine growth inhibitors, transforming growth factor-beta and insulin-like growth factor binding protein-6, in a calcium- and cell density-dependent manner". J. Biol. Chem. 270 (21): 12373–9. doi:10.1074/jbc.270.21.12373. PMID 7539002.
Delhanty PJ, Hill DJ, Shimasaki S, Han VK (1993). "Insulin-like growth factor binding protein-4, -5 and -6 mRNAs in the human fetus: localization to sites of growth and differentiation?". Growth Regul. 3 (1): 8–11. PMID 7683540.
Bach LA, Hsieh S, Sakano K, et al. (1993). "Binding of mutants of human insulin-like growth factor II to insulin-like growth factor binding proteins 1-6". J. Biol. Chem. 268 (13): 9246–54. doi:10.1016/S0021-9258(18)98342-0. PMID 7683646.
Wegmann BR, Schöneberger HJ, Kiefer PE, et al. (1993). "Molecular cloning of IGFBP-5 from SCLC cell lines and expression of IGFBP-4, IGFBP-5 and IGFBP-6 in lung cancer cell lines and primary tumours". Eur. J. Cancer. 29A (11): 1578–84. doi:10.1016/0959-8049(93)90298-T. PMID 7692907.
Neumann GM, Marinaro JA, Bach LA (1998). "Identification of O-glycosylation sites and partial characterization of carbohydrate structure and disulfide linkages of human insulin-like growth factor binding protein 6". Biochemistry. 37 (18): 6572–85. doi:10.1021/bi972894e. PMID 9572875.
Neumann GM, Bach LA (1999). "The N-terminal disulfide linkages of human insulin-like growth factor-binding protein-6 (hIGFBP-6) and hIGFBP-1 are different as determined by mass spectrometry". J. Biol. Chem. 274 (21): 14587–94. doi:10.1074/jbc.274.21.14587. PMID 10329650.
Wong MS, Fong CC, Yang M (1999). "Biosensor measurement of the interaction kinetics between insulin-like growth factors and their binding proteins". Biochim. Biophys. Acta. 1432 (2): 293–301. doi:10.1016/S0167-4838(99)00106-5. PMID 10407151.
Yu H, Mistry J, Nicar MJ, et al. (1999). "Insulin-like growth factors (IGF-I, free IGF-I and IGF-II) and insulin-like growth factor binding proteins (IGFBP-2, IGFBP-3, IGFBP-6, and ALS) in blood circulation". J. Clin. Lab. Anal. 13 (4): 166–72. doi:10.1002/(SICI)1098-2825(1999)13:4<166::AID-JCLA5>3.0.CO;2-X. PMC 6808158. PMID 10414596.
Dailly YP, Zhou Y, Linkhart TA, et al. (2001). "Structure and characterization of the human insulin-like growth factor binding protein (IGFBP)-6 promoter: identification of a functional retinoid response element". Biochim. Biophys. Acta. 1518 (1–2): 145–51. doi:10.1016/S0167-4781(01)00192-0. PMID 11267670.
Weinzimer SA, Gibson TB, Collett-Solberg PF, et al. (2001). "Transferrin is an insulin-like growth factor-binding protein-3 binding protein". J. Clin. Endocrinol. Metab. 86 (4): 1806–13. doi:10.1210/jcem.86.4.7380. PMID 11297622.

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[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000023046 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1850258-4] Kiefer MC, Ioh RS, Bauer DM, Zapf J (May 1991). "Molecular cloning of a new human insulin-like growth factor binding protein". Biochem Biophys Res Commun. 176 (1): 219–25. doi:10.1016/0006-291X(91)90912-Q. PMID 1850258.

[pmid10087296-5] Ehrenborg E, Zazzi H, Lagercrantz S, Granqvist M, Hillerbrand U, Allander SV, Larsson C, Luthman H (May 1999). "Characterization and chromosomal localization of the human insulin-like growth factor-binding protein 6 gene". Mamm Genome. 10 (4): 376–80. doi:10.1007/s003359901005. PMID 10087296. S2CID 21499958.

[entrez-6] "Entrez Gene: IGFBP6 insulin-like growth factor binding protein 6".

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v t e Proteins: carrier proteins
Fatty acid	FABP1 FABP2 FABP3 FABP4 FABP5 FABP6 FABP7
Hormone	peptide hormone: Follistatin Growth hormone binding protein Insulin-like growth factor binding protein IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 IGFBP7 Neurophysins Neurophysin I II steroid hormone: Sex hormone binding globulin/Androgen binding protein Transcortin Thyroxine-binding globulin Transthyretin
Metal/element	calcium Calcium-binding protein Calmodulin-binding proteins copper Ceruloplasmin iron Iron-binding proteins Transferrin receptor
Vitamin	Retinol binding protein 1 2 3 4 Transcobalamin
Pigment	Plant Light-Harvesting Complex Orange Carotenoid Protein Phycobiliprotein Photosynthetic Reaction Centers Phytochrome Rhodopsin
Other	Acyl carrier protein Adaptor protein Cholesterylester transfer protein F-box protein GTP-binding protein Latent TGF-beta binding protein Major urinary proteins Membrane transport protein Odorant binding protein

References

Further reading