Bone morphogenetic protein receptor

TKL Ser/Thr protein kinase family
TKL Ser/Thr protein kinase family
Identifiers
Symbol	TKL
Membranome	1216

Bone morphogenetic protein receptors are serine-threonine kinase receptors. Transforming growth factor beta family proteins bind to these receptors.^[1] There are four bone morphogenetic protein receptors:^[2]

Structure

Both type 1 and 2 bone morphogenetic protein receptors have a single transmembrane segment. Additionally, both types have a cysteine-rich extracellular domain and a cytoplasmic serine threonine kinase domain.^[3] Type 1 contains a glycine-serine-rich domain to be phosphorylated by type 2 kinase domain, initiating the signaling transduction pathway of the SMAD signaling cascade.^[3] The wrist epitope motif on BMP-2 has a high-affinity binding site for BMPR-IA. The knuckle epitope motif on BMP-2 has a low-affinity binding site for BMPR-II.^[4]

References

^ Miyazono K, Kamiya Y, Morikawa M (January 2010). "Bone morphogenetic protein receptors and signal transduction". Journal of Biochemistry. 147 (1): 35–51. doi:10.1093/jb/mvp148. PMID 19762341.
^ Pasche B (December 2008). "The TGF Family. Cold Spring Harbor Monograph Series, Volume 50. Edited by Rik Derynck, Kohei Miyazono. Cold Spring Harbor (New York): Cold Spring Harbor Laboratory Press. xiv-1114 p.; ill.; index. 9780879697525. 2008". The Quarterly Review of Biology. 83 (4): 405–405. doi:10.1086/596254.
^ ^a ^b Mace PD, Cutfield JF, Cutfield SM (December 2006). "High resolution structures of the bone morphogenetic protein type II receptor in two crystal forms: implications for ligand binding". Biochemical and Biophysical Research Communications. 351 (4): 831–8. doi:10.1016/j.bbrc.2006.10.109. PMID 17094948.
^ Miyazono K, Shimanuki T (January 2008). "Chapter 55: Bone morphogenetic protein receptors and actions.". In Bilezikian JP, Raisz LG, Martin TJ (eds.). Principles of bone biology (Third ed.). San Diego: Academic Press. pp. 1177–1196. doi:10.1016/B978-0-12-373884-4.00069-0. ISBN 978-0-12-373884-4.

External links

Bone+Morphogenetic+Protein+Receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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[1] Miyazono K, Kamiya Y, Morikawa M (January 2010). "Bone morphogenetic protein receptors and signal transduction". Journal of Biochemistry. 147 (1): 35–51. doi:10.1093/jb/mvp148. PMID 19762341.

[2] Pasche B (December 2008). "The TGF Family. Cold Spring Harbor Monograph Series, Volume 50. Edited by Rik Derynck, Kohei Miyazono. Cold Spring Harbor (New York): Cold Spring Harbor Laboratory Press. xiv-1114 p.; ill.; index. 9780879697525. 2008". The Quarterly Review of Biology. 83 (4): 405–405. doi:10.1086/596254.

[Mace_2006-3] Mace PD, Cutfield JF, Cutfield SM (December 2006). "High resolution structures of the bone morphogenetic protein type II receptor in two crystal forms: implications for ligand binding". Biochemical and Biophysical Research Communications. 351 (4): 831–8. doi:10.1016/j.bbrc.2006.10.109. PMID 17094948.

[4] Miyazono K, Shimanuki T (January 2008). "Chapter 55: Bone morphogenetic protein receptors and actions.". In Bilezikian JP, Raisz LG, Martin TJ (eds.). Principles of bone biology (Third ed.). San Diego: Academic Press. pp. 1177–1196. doi:10.1016/B978-0-12-373884-4.00069-0. ISBN 978-0-12-373884-4.

[1]

[2]

[3]

[4]

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

Structure

See also

References

External links