A | B | C | D | E | F | G | H | CH | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 0 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9
CYREN | |||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||
Aliases | CYREN, MRI, chromosome 7 open reading frame 49, MRI-2, C7orf49, cell cycle regulator of NHEJ | ||||||||||||||||||||||||||||||
External IDs | OMIM: 616980; MGI: 1925662; HomoloGene: 49745; GeneCards: CYREN; OMA:CYREN - orthologs | ||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||
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Cell cycle regulator of non-homologous end joining is a protein that in humans is encoded by the CYREN gene.
It prevents classical non-homologous end joining, a method of repair of double-stranded DNA breaks.[5] This protein is therefore important in regulating DNA repair.
When alternatively spliced, is predicted to produce three different micropeptides.[6]
- MRI-1 was previously found to be a modulator of retrovirus infection.[6]
- MRI-2 may be important in non-homologous end joining (NHEJ) of DNA double strand breaks. In Co-Immunoprecipitation experiments, MRI-2 bound to Ku70 and Ku80, two subunits of Ku, which play a major role in the NHEJ pathway.[6]
- MRI-3
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000122783 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000046806 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Arnoult N, Correia A, Ma J, Merlo A, Garcia-Gomez S, Maric M, Tognetti M, Benner CW, Boulton SJ, Saghatelian A, Karlseder J (September 2017). "Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN". Nature. 549 (7673): 548–552. Bibcode:2017Natur.549..548A. doi:10.1038/nature24023. PMC 5624508. PMID 28959974.
- ^ a b c Slavoff SA, Heo J, Budnik BA, Hanakahi LA, Saghatelian A (April 2014). "A human short open reading frame (sORF)-encoded polypeptide that stimulates DNA end joining". The Journal of Biological Chemistry. 289 (16): 10950–7. doi:10.1074/jbc.c113.533968. PMC 4036235. PMID 24610814.
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