60S ribosomal protein L18

RPL18
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4UG0, 4V6X, 5AJ0, 4UJD, 4D67, 4D5Y, 4UJE, 4UJC
Identifiers
Aliases	RPL18, L18, ribosomal protein L18, DBA18
External IDs	OMIM: 604179; MGI: 98003; HomoloGene: 756; GeneCards: RPL18; OMA:RPL18 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	48,619,184 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	45,370,260 bp
RNA expression pattern
	Top expressed in
	nipple; ; human penis; ; skin of thigh; ; skin of hip; ; urethra; ; right uterine tube; ; pylorus; ; vulva; ; left ovary; ; skin of arm;
	Top expressed in
	epiblast; ; urinary bladder; ; embryo; ; bone marrow; ; adrenal gland; ; yolk sac; ; embryo; ; ventricular zone; ; lip; ; morula;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	RNA binding; structural constituent of ribosome;
Cellular component	ribosome; membrane; focal adhesion; intracellular anatomical structure; nucleolus; cytosolic large ribosomal subunit; nucleus; cytoplasm; endoplasmic reticulum; cytosol; rough endoplasmic reticulum; polysomal ribosome;
Biological process	viral transcription; SRP-dependent cotranslational protein targeting to membrane; translational initiation; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; rRNA processing; protein biosynthesis; cytoplasmic translation;
	Sources:Amigo / QuickGO
Orthologs
	6141
	19899
	ENSG00000063177
	ENSMUSG00000059070
	Q07020
	P35980
	NM_000979; NM_001270490
	NM_009077
	NP_000970; NP_001257419
	NP_033103
	Wikidata
View/Edit Human	View/Edit Mouse

60S ribosomal protein L18 is a protein that in humans is encoded by the RPL18 gene.^[5]^[6]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L18E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000063177 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000059070 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Puder M, Barnard GF, Staniunas RJ, Steele GD Jr, Chen LB (Dec 1993). "Nucleotide and deduced amino acid sequence of human ribosomal protein L18". Biochim Biophys Acta. 1216 (1): 134–6. doi:10.1016/0167-4781(93)90050-n. PMID 8218404.
^ ^a ^b "Entrez Gene: RPL18 ribosomal protein L18".

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Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50. doi:10.1016/0378-1119(94)90433-2. PMID 7821789.
Kenmochi N, Kawaguchi T, Rozen S, et al. (1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
Yoshihama M, Uechi T, Asakawa S, et al. (2002). "The Human Ribosomal Protein Genes: Sequencing and Comparative Analysis of 73 Genes". Genome Res. 12 (3): 379–90. doi:10.1101/gr.214202. PMC 155282. PMID 11875025.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Odintsova TI, Müller EC, Ivanov AV, et al. (2004). "Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing". J. Protein Chem. 22 (3): 249–58. doi:10.1023/A:1025068419698. PMID 12962325. S2CID 10710245.
Reuter TY, Medhurst AL, Waisfisz Q, et al. (2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport". Exp. Cell Res. 289 (2): 211–21. doi:10.1016/S0014-4827(03)00261-1. PMID 14499622.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Kullberg M, Nilsson MA, Arnason U, et al. (2006). "Housekeeping genes for phylogenetic analysis of eutherian relationships". Mol. Biol. Evol. 23 (8): 1493–503. doi:10.1093/molbev/msl027. PMID 16751257.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000063177 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000059070 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8218404-5] Puder M, Barnard GF, Staniunas RJ, Steele GD Jr, Chen LB (Dec 1993). "Nucleotide and deduced amino acid sequence of human ribosomal protein L18". Biochim Biophys Acta. 1216 (1): 134–6. doi:10.1016/0167-4781(93)90050-n. PMID 8218404.

[entrez-6] "Entrez Gene: RPL18 ribosomal protein L18".

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References

Further reading