OPN1SW

OPN1SW
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1KPN
Identifiers
Aliases	OPN1SW, BCP, BOP, CBT, opsin 1 (cone pigments), short-wave-sensitive, opsin 1, short wave sensitive
External IDs	OMIM: 613522 MGI: 99438 HomoloGene: 1291 GeneCards: OPN1SW
Gene location (Human)
Chr.	Chromosome 7 (human)
End	128,775,794 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	29,388,467 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; Brodmann area 46; ; stromal cell of endometrium; ; retinal pigment epithelium; ; Achilles tendon; ; prefrontal cortex; ; ganglionic eminence; ; exocrine gland; ; islet of Langerhans; ; blood;
	Top expressed in
	outer nuclear layer; ; retinal pigment epithelium; ; morula; ; esophagus; ; right ventricle; ; lip; ; striated muscle tissue; ; skeletal muscle tissue; ; blastocyst; ; stomach;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; photoreceptor activity; signal transducer activity; G protein-coupled photoreceptor activity; signaling receptor activity;
Cellular component	integral component of membrane; integral component of plasma membrane; membrane; photoreceptor outer segment; photoreceptor disc membrane;
Biological process	response to stimulus; signal transduction; visual perception; retinoid metabolic process; phototransduction; detection of visible light; G protein-coupled receptor signaling pathway; cellular response to light stimulus;
	Sources:Amigo / QuickGO
Orthologs
	611
	12057
	ENSG00000128617
	ENSMUSG00000058831
	P03999
	P51491
	NM_001708; NM_001385125
	NM_007538
	NP_001699
	NP_031564
	Wikidata
View/Edit Human	View/Edit Mouse

Blue-sensitive opsin is a protein that in humans is encoded by the OPN1SW gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000128617 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000058831 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nathans J, Thomas D, Hogness DS (Apr 1986). "Molecular genetics of human color vision: the genes encoding blue, green, and red pigments". Science. 232 (4747): 193–202. Bibcode:1986Sci...232..193N. CiteSeerX 10.1.1.461.5915. doi:10.1126/science.2937147. PMID 2937147.
^ Fitzgibbon J, Appukuttan B, Gayther S, Wells D, Delhanty J, Hunt DM (Feb 1994). "Localisation of the human blue cone pigment gene to chromosome band 7q31.3-32". Hum Genet. 93 (1): 79–80. doi:10.1007/bf00218919. PMID 8270261. S2CID 43548690.
^ "Entrez Gene: OPN1SW opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)".

Applebury ML, Hargrave PA (1987). "Molecular biology of the visual pigments". Vision Res. 26 (12): 1881–95. doi:10.1016/0042-6989(86)90115-X. PMID 3303660. S2CID 34038855.
Swanson WH, Cohen JM (2003). "Color vision". Ophthalmology Clinics of North America. 16 (2): 179–203. doi:10.1016/S0896-1549(03)00004-X. PMID 12809157.
Weitz CJ, Went LN, Nathans J (1992). "Human tritanopia associated with a third amino acid substitution in the blue-sensitive visual pigment". Am. J. Hum. Genet. 51 (2): 444–6. PMC 1682686. PMID 1386496.
Weitz CJ, Miyake Y, Shinzato K, et al. (1992). "Human tritanopia associated with two amino acid substitutions in the blue-sensitive opsin". Am. J. Hum. Genet. 50 (3): 498–507. PMC 1684278. PMID 1531728.
Oprian DD, Asenjo AB, Lee N, Pelletier SL (1992). "Design, chemical synthesis, and expression of genes for the three human color vision pigments". Biochemistry. 30 (48): 11367–72. doi:10.1021/bi00112a002. PMID 1742276.
Sarkar G, Sommer SS (1989). "Access to a messenger RNA sequence or its protein product is not limited by tissue or species specificity". Science. 244 (4902): 331–4. Bibcode:1989Sci...244..331S. doi:10.1126/science.2565599. PMID 2565599.
Nathans J, Piantanida TP, Eddy RL, et al. (1986). "Molecular genetics of inherited variation in human color vision". Science. 232 (4747): 203–10. Bibcode:1986Sci...232..203N. doi:10.1126/science.3485310. PMID 3485310.
Shimmin LC, Mai P, Li WH (1997). "Sequences and evolution of human and squirrel monkey blue opsin genes". J. Mol. Evol. 44 (4): 378–82. Bibcode:1997JMolE..44..378S. doi:10.1007/PL00006157. PMID 9089077. S2CID 6425474.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Gunther KL, Neitz J, Neitz M (2006). "A novel mutation in the short-wavelength-sensitive cone pigment gene associated with a tritan color vision defect". Vis. Neurosci. 23 (3–4): 403–9. doi:10.1017/S0952523806233169. PMID 16961973. S2CID 3748083.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000128617 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000058831 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2937147-5] Nathans J, Thomas D, Hogness DS (Apr 1986). "Molecular genetics of human color vision: the genes encoding blue, green, and red pigments". Science. 232 (4747): 193–202. Bibcode:1986Sci...232..193N. CiteSeerX 10.1.1.461.5915. doi:10.1126/science.2937147. PMID 2937147.

[pmid8270261-6] Fitzgibbon J, Appukuttan B, Gayther S, Wells D, Delhanty J, Hunt DM (Feb 1994). "Localisation of the human blue cone pigment gene to chromosome band 7q31.3-32". Hum Genet. 93 (1): 79–80. doi:10.1007/bf00218919. PMID 8270261. S2CID 43548690.

[entrez-7] "Entrez Gene: OPN1SW opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)".

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[3]

[4]

[5]

[6]

[7]

See also

References

Further reading