H2AB2

H2AB2
Identifiers
Aliases	H2AB2, H2A.Bbd, H2A histone family member B2, H2A.B variant histone 2, H2AFB2, H2AB3, H2A.B.1
External IDs	MGI: 3644875; HomoloGene: 129517; GeneCards: H2AB2; OMA:H2AB2 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	155,381,299 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	119,222,792 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; gastric mucosa; ; canal of the cervix; ; spleen; ; blood; ; right coronary artery; ; sural nerve; ; fundus; ; ganglionic eminence; ; monocyte;
	Top expressed in
	testicle; ; spermatid; ; cerebellum; ; hypothalamus; ; mesencephalon; ; superior frontal gyrus; ; spleen; ; hippocampal formation; ; hippocampus proper; ; thymus;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein heterodimerization activity; DNA binding;
Cellular component	nucleosome; nucleus; chromosome;
Biological process	nucleosome assembly; mRNA processing; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	474381
	624957
	ENSG00000277858
	ENSMUSG00000083616
	P0C5Z0
	S4R1G7
	NM_001017991
	NM_001281531
	NP_001017991
	NP_001268460
	Wikidata
View/Edit Human	View/Edit Mouse

Histone H2A-Bbd type 2/3 also known as H2A Barr body-deficient is a histone protein that in humans is encoded by the H2AFB2 gene (H2A histone family, member B1).^[5]

Function

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. This gene is part of a region that is repeated three times on chromosome X, once in intron 22 of the F8 gene and twice closer to the Xq telomere. This record represents the middle copy.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000277858 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000083616 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: H2A histone family".

Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Chadwick BP, Willard HF (2001). "A Novel Chromatin Protein, Distantly Related to Histone H2a, Is Largely Excluded from the Inactive X Chromosome". J. Cell Biol. 152 (2): 375–84. doi:10.1083/jcb.152.2.375. PMC 2199617. PMID 11266453.
Bao Y, Konesky K, Park YJ, et al. (2004). "Nucleosomes containing the histone variant H2A.Bbd organize only 118 base pairs of DNA". EMBO J. 23 (16): 3314–24. doi:10.1038/sj.emboj.7600316. PMC 514500. PMID 15257289.
Naylor JA, Buck D, Green P, et al. (1995). "Investigation of the factor VIII intron 22 repeated region (int22h) and the associated inversion junctions". Hum. Mol. Genet. 4 (7): 1217–24. doi:10.1093/hmg/4.7.1217. PMID 8528212.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000277858 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000083616 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: H2A histone family".

[1]

[2]

[3]

[4]

[5]

Function

References

Further reading