Delapril

Delapril
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	C09AA12 (WHO) ;
Identifiers
	IUPAC name 2-(2S)-2-(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-ylaminopropanoylaminoacetic acid;
CAS Number	83435-66-9 ;
PubChem CID	5362116;
ChemSpider	4514931 ;
UNII	W77UAL9THI;
KEGG	D07781 ;
ChEMBL	ChEMBL2106126 ;
Chemical and physical data
Formula	C26H32N2O5
Molar mass	452.551 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(OCC)C@@H(NC@H(C(=O)N(CC(=O)O)C2Cc1ccccc1C2)C)CCc3ccccc3;
	InChI InChI=1S/C26H32N2O5/c1-3-33-26(32)23(14-13-19-9-5-4-6-10-19)27-18(2)25(31)28(17-24(29)30)22-15-20-11-7-8-12-21(20)16-22/h4-12,18,22-23,27H,3,13-17H2,1-2H3,(H,29,30)/t18-,23-/m0/s1 ; Key:WOUOLAUOZXOLJQ-MBSDFSHPSA-N ;
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Delapril (INN, also known as alindapril) is an ACE inhibitor used as an antihypertensive drug^[1] in some European and Asian countries but not in America.^[2] It is taken orally, available in 15 mg and 30 mg tablets.^[3]

Mechanismedit

Delapril is a prodrug; it is converted into two active metabolites, 5-hydroxy delapril diacid and delapril diacid. These metabolites bind completely to and inhibit angiotensin-converting enzyme (ACE), hence blocking angiotensin I to angiotensin II conversion. The resulting vasodilation prevents the vasoconstrictive effects of angiotensin II. Angiotensin II-induced aldosterone secretion by the adrenal cortex is also decreased by Delapril, leading to increases in excretion of sodium and therefore increases water outflow.^[4]

Referencesedit

^ Otero ML (2007). "Manidipine-delapril combination in the management of hypertension". Vascular Health and Risk Management. 3 (3): 255–63. PMC 2293964. PMID 17703633.
^ "Delapril". Drugs.com.
^ "Delapril". cursoenarm.net. Retrieved 2016-08-28.
^ "Delapril". Pubchem. U.S. National Library of Medicine. Retrieved 2016-08-28.

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[1] Otero ML (2007). "Manidipine-delapril combination in the management of hypertension". Vascular Health and Risk Management. 3 (3): 255–63. PMC 2293964. PMID 17703633.

[2] "Delapril". Drugs.com.

[3] "Delapril". cursoenarm.net. Retrieved 2016-08-28.

[4] "Delapril". Pubchem. U.S. National Library of Medicine. Retrieved 2016-08-28.

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v t e Antihypertensive drugs acting on the renin–angiotensin system (C09)
ACE inhibitors ("-pril")	Sulfhydryl-containing: Captopril Rentiapril Zofenopril Dicarboxylate-containing: Enalapril^# Benazepril Cilazapril Delapril Imidapril Lisinopril (+amlodipine, +HCT) Moexipril Perindopril (+indapamide) Quinapril (+HCT) Ramipril Spirapril Temocapril Trandolapril Phosphonate-containing: Ceronapril Fosinopril (+HCT) Other/ungrouped: Alacepril
AIIRAs ("-sartan")	Azilsartan Candesartan Eprosartan Fimasartan Irbesartan (+HCT) Losartan (+HCT) Olmesartan (+amlodipine, +amlodipine and HCT, +HCT) Tasosartan^§ Telmisartan (+amlodipine, +HCT) Valsartan (+amlodipine, +amlodipine and HCT, +HCT, +nebivolol)
Renin inhibitors ("-kiren")	Aliskiren (+amlodipine, +HCT, +amlodipine and HCT) Remikiren^§
Dual ACE/NEP inhibitors	Gemopatrilat Ilepatril Omapatrilat Sampatrilat
Neprilysin inhibitors	Sacubitril (+valsartan)
^#WHO-EM ^‡Withdrawn from market Clinical trials: ^†Phase III ^§Never to phase III