Adapalene/benzoyl peroxide

Adapalene/benzoyl peroxide
Combination of

Adapalene	Retinoid
Benzoyl peroxide	Peroxide
Clinical data
Trade names	Epiduo, Epiduo Forte
Routes of administration	Topical
ATC code	D10AD53 (WHO) D10AE51 (WHO)
Legal status
Legal status	US: ℞-only^[1]^[2] In general: ℞ (Prescription only)
Identifiers
CAS Number	1194805-81-6^N
KEGG	D10792^N
^NY (what is this?) (verify)

Adapalene/benzoyl peroxide, sold under the brand name Epiduo among others, is a fixed-dose combination medication for the treatment of severe acne vulgaris.^[1]^[2] It consists of a combination of adapalene and benzoyl peroxide in a topical gel formulation.^[1]^[2]

It is available as a generic medication.^[3]

Medical uses

Adapalene/benzoyl peroxide is indicated for the topical treatment of acne vulgaris.^[1]^[2]

Side effects

Commonly reported side effects include the following:^[1]^[2]

Research

Meta-analysis of clinical trials has shown this combined therapy to be more effective than either of its ingredients by themselves.^[4]

The use of adapalene/benzoyl peroxide in combination with oral antibiotics (lymecycline) has been studied;^[5] the combination was well tolerated and showed an improved success rate compared to those receiving only antibiotics (47.6% vs. 33.7%, P = 0.002).

References

^ ^a ^b ^c ^d ^e "Epiduo- adapalene and benzoyl peroxide gel". DailyMed. 21 February 2018. Retrieved 15 May 2022.
^ ^a ^b ^c ^d ^e "Epiduo Forte- adapalene and benzoyl peroxide gel". DailyMed. 27 April 2022. Retrieved 15 May 2022.
^ "Competitive Generic Therapy Approvals". U.S. Food and Drug Administration (FDA). 29 June 2023. Archived from the original on 29 June 2023. Retrieved 29 June 2023.
^ Tan J, Gollnick HP, Loesche C, Ma YM, Gold LS (August 2011). "Synergistic efficacy of adapalene 0.1%-benzoyl peroxide 2.5% in the treatment of 3855 acne vulgaris patients". The Journal of Dermatological Treatment. 22 (4): 197–205. doi:10.3109/09546631003681094. PMID 20666678. S2CID 34631151.
^ Dréno B, Kaufmann R, Talarico S, Torres Lozada V, Rodríguez-Castellanos MA, Gómez-Flores M, et al. (August 2011). "Combination therapy with adapalene-benzoyl peroxide and oral lymecycline in the treatment of moderate to severe acne vulgaris: a multicentre, randomized, double-blind controlled study". The British Journal of Dermatology. 165 (2): 383–90. doi:10.1111/j.1365-2133.2011.10374.x. PMID 21495995. S2CID 21793660.

External links

"Adapalene mixture with benzoyl peroxide". Drug Information Portal. U.S. National Library of Medicine.

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Category
Commons

v t e Acne-treating agents (D10)
Antibacterial	Azelaic acid Benzoyl peroxide^# 8-Hydroxyquinoline Blue light therapy Tea tree oil
Keratolytic	Glycolic acid Salicylic acid^# Sulfur Benzoyl peroxide^#
Anti-inflammatory	Niacinamide Ibuprofen^# Aspirin^# Red light therapy
Antibiotics	Clindamycin Dapsone Erythromycin Sulfacetamide Tetracyclines (Lymecycline Minocycline Doxycycline)
Hormonal	Antiandrogens Bicalutamide Cyproterone acetate Drospirenone Flutamide Spironolactone) Estrogens Estradiol Ethinylestradiol
Retinoids	Adapalene Isotretinoin Motretinide Tazarotene Tretinoin Trifarotene
Other	Epristeride Mesulfen Pelretin Stridex Tioxolone
Combinations	Adapalene/benzoyl peroxide Clindamycin/adapalene/benzoyl peroxide Clindamycin/benzoyl peroxide Clindamycin/tretinoin Erythromycin/benzoyl peroxide Erythromycin/isotretinoin Sulfacetamide/sulfur Tretinoin/benzoyl peroxide
^#WHO-EM ^‡Withdrawn from market Clinical trials: ^†Phase III ^§Never to phase III