Somatostatin family

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary
PDB	1p2wA:99-116

Somatostatin/cortistatin family
Somatostatin/cortistatin family
Identifiers
Symbol	Somatostatin
Pfam	PF03002
InterPro	IPR004250
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary
PDB	1p2wA:99-116

The somatostatin family is a protein family with somatostatin as titular member, a hormone which inhibits the release of the pituitary somatotropin (growth hormone) and inhibits the release of glucagon and insulin from the pancreas of fasted animals. Cortistatin is a cortical neuropeptide with neuronal depressant and sleep-modulating properties.^[1]

Human proteins from this family

Cortistatin (CORT)
Somatostatin (SST)

References

^ De Lecea L, Danielson PE, Criado JR, Prospero-garcia O, Gautvik KM, Schweitzer P, Dunlop CL, Siggins GR, Henriksen SJ, Sutcliffe JG (1996). "A cortical neuropeptide with neuronal depressant and sleep-modulating properties". Nature. 381 (6579): 242–245. Bibcode:1996Natur.381..242D. doi:10.1038/381242a0. PMID 8622767. S2CID 3931102.

This article incorporates text from the public domain Pfam and InterPro: IPR004250

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[PUB00007453-1] De Lecea L, Danielson PE, Criado JR, Prospero-garcia O, Gautvik KM, Schweitzer P, Dunlop CL, Siggins GR, Henriksen SJ, Sutcliffe JG (1996). "A cortical neuropeptide with neuronal depressant and sleep-modulating properties". Nature. 381 (6579): 242–245. Bibcode:1996Natur.381..242D. doi:10.1038/381242a0. PMID 8622767. S2CID 3931102.

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