SYT5

SYT5
Identifiers
Aliases	SYT5, synaptotagmin 5
External IDs	OMIM: 600782; MGI: 1926368; HomoloGene: 55722; GeneCards: SYT5; OMA:SYT5 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	55,180,289 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	4,550,540 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; cingulate gyrus; ; nucleus accumbens; ; caudate nucleus; ; dorsolateral prefrontal cortex; ; Brodmann area 9; ; putamen; ; Brodmann area 10; ; amygdala; ; pituitary gland;
	Top expressed in
	superior frontal gyrus; ; entorhinal cortex; ; tongue; ; ventromedial nucleus; ; supraoptic nucleus; ; nucleus accumbens; ; hippocampus proper; ; arcuate nucleus; ; primary motor cortex; ; prefrontal cortex;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	clathrin binding; metal ion binding; protein heterodimerization activity; calcium-dependent phospholipid binding; syntaxin binding; SNARE binding; phosphatidylinositol-4,5-bisphosphate binding; phosphatidylserine binding; calcium ion binding;
Cellular component	integral component of membrane; endosome; membrane; synapse; synaptic vesicle membrane; cell junction; neuronal cell body; recycling endosome membrane; perinuclear region of cytoplasm; neuron projection; dense core granule; cytoplasmic vesicle; plasma membrane; proximal neuron projection; integral component of neuronal dense core vesicle membrane; axon; exocytic vesicle;
Biological process	synaptic vesicle endocytosis; chemical synaptic transmission; vesicle fusion; regulation of calcium ion-dependent exocytosis; calcium ion-regulated exocytosis of neurotransmitter; regulation of dopamine secretion; synaptic vesicle exocytosis; vesicle-mediated transport; calcium-ion regulated exocytosis; cellular response to calcium ion;
	Sources:Amigo / QuickGO
Orthologs
	6861
	53420
	ENSG00000129990
	ENSMUSG00000004961
	O00445
	Q9R0N5
	NM_001297774; NM_003180
	NM_016908; NM_001360421; NM_001360422
	NP_001284703; NP_003171
	NP_001347350; NP_001347351
	Wikidata
View/Edit Human	View/Edit Mouse

Synaptotagmin-5 is a protein that in humans is encoded by the SYT5 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000129990 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000004961 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Craxton M, Olsen A, Goedert M (Jul 1997). "Human synaptotagmin V (SYT5): sequence, genomic structure, and chromosomal location". Genomics. 42 (1): 165–9. doi:10.1006/geno.1997.4722. PMID 9177789.
^ "Entrez Gene: SYT5 synaptotagmin V".

Hudson AW, Birnbaum MJ (1995). "Identification of a nonneuronal isoform of synaptotagmin". Proc. Natl. Acad. Sci. U.S.A. 92 (13): 5895–9. Bibcode:1995PNAS...92.5895H. doi:10.1073/pnas.92.13.5895. PMC 41608. PMID 7597049.
Perin MS (1996). "Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin". Biochemistry. 35 (43): 13808–16. doi:10.1021/bi960853x. PMID 8901523.
Fukuda M, Kanno E, Mikoshiba K (1999). "Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and X." J. Biol. Chem. 274 (44): 31421–7. doi:10.1074/jbc.274.44.31421. PMID 10531343.
Craxton M, Goedert M (1999). "Alternative splicing of synaptotagmins involving transmembrane exon skipping". FEBS Lett. 460 (3): 417–22. doi:10.1016/S0014-5793(99)01382-4. PMID 10556508. S2CID 19207631.
Mizutani A, Fukuda M, Ibata K, et al. (2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". J. Biol. Chem. 275 (13): 9823–31. doi:10.1074/jbc.275.13.9823. PMID 10734137.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Sreenath AS, Kumar KR, Reddy GV, et al. (2005). "Evidence for the association of synaptotagmin with glutathione S-transferases: implications for a novel function in human breast cancer". Clin. Biochem. 38 (5): 436–43. doi:10.1016/j.clinbiochem.2005.01.009. PMID 15820774.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000129990 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000004961 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9177789-5] Craxton M, Olsen A, Goedert M (Jul 1997). "Human synaptotagmin V (SYT5): sequence, genomic structure, and chromosomal location". Genomics. 42 (1): 165–9. doi:10.1006/geno.1997.4722. PMID 9177789.

[entrez-6] "Entrez Gene: SYT5 synaptotagmin V".

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References

Further reading