SLC13A3

SLC13A3
Identifiers
Aliases	SLC13A3, NADC3, SDCT2, solute carrier family 13 member 3, ARLIAK
External IDs	OMIM: 606411 MGI: 2149635 HomoloGene: 11266 GeneCards: SLC13A3
Gene location (Human)
Chr.	Chromosome 20 (human)
End	46,684,467 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	165,315,150 bp
RNA expression pattern
	Top expressed in
	kidney tubule; ; kidney; ; metanephric glomerulus; ; oocyte; ; secondary oocyte; ; olfactory bulb; ; corpus callosum; ; right lobe of liver; ; placenta; ; inferior olivary nucleus;
	Top expressed in
	kidney; ; median eminence; ; retinal pigment epithelium; ; proximal tubule; ; pontine nuclei; ; mammillary body; ; olfactory tubercle; ; arcuate nucleus; ; inferior colliculus; ; ciliary body;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transporter activity; symporter activity; succinate transmembrane transporter activity; sodium:dicarboxylate symporter activity; citrate transmembrane transporter activity; high-affinity sodium:dicarboxylate symporter activity;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; extracellular exosome;
Biological process	dicarboxylic acid transport; sodium ion transport; ion transport; succinate transmembrane transport; citrate transport; transmembrane transport; transport;
	Sources:Amigo / QuickGO
Orthologs
	64849
	114644
	ENSG00000158296
	ENSMUSG00000018459
	Q8WWT9
	Q91Y63
	NM_022829; NM_001011554; NM_001193339; NM_001193340; NM_001193342
	NM_054055
	NP_001011554; NP_001180268; NP_001180269; NP_001180271; NP_073740
	NP_473396
	Wikidata
View/Edit Human	View/Edit Mouse

Solute carrier family 13 member 3 also called sodium-dependent dicarboxylate transporter (NaDC3) is a protein that in humans is encoded by the SLC13A3 gene.^[5]^[6]^[7]

Mammalian sodium-dicarboxylate cotransporters transport succinate and other Krebs cycle intermediates. They fall into 2 categories based on their substrate affinity: low affinity and high affinity. Both the low- and high-affinity transporters play an important role in the handling of citrate by the kidneys. The protein encoded by this gene represents the high-affinity form. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been characterized yet.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000158296 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000018459 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wang H, Fei YJ, Kekuda R, Yang-Feng TL, Devoe LD, Leibach FH, Prasad PD, Ganapathy V (Jun 2000). "Structure, function, and genomic organization of human Na(+)-dependent high-affinity dicarboxylate transporter". Am J Physiol Cell Physiol. 278 (5): C1019–30. doi:10.1152/ajpcell.2000.278.5.C1019. PMID 10794676. S2CID 39532742.
^ Huang W, Wang H, Kekuda R, Fei YJ, Friedrich A, Wang J, Conway SJ, Cameron RS, Leibach FH, Ganapathy V (Nov 2000). "Transport of N-acetylaspartate by the Na(+)-dependent high-affinity dicarboxylate transporter NaDC3 and its relevance to the expression of the transporter in the brain". J Pharmacol Exp Ther. 295 (1): 392–403. PMID 10992006.
^ ^a ^b "Entrez Gene: SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3".

Markovich D, Murer H (2004). "The SLC13 gene family of sodium sulphate/carboxylate cotransporters". Pflügers Arch. 447 (5): 594–602. doi:10.1007/s00424-003-1128-6. PMID 12915942. S2CID 7609066.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Burckhardt BC, Lorenz J, Kobbe C, Burckhardt G (2005). "Substrate specificity of the human renal sodium dicarboxylate cotransporter, hNaDC-3, under voltage-clamp conditions". Am. J. Physiol. Renal Physiol. 288 (4): F792–9. doi:10.1152/ajprenal.00360.2004. PMID 15561973.
Bai X, Chen X, Feng Z, et al. (2006). "Identification of basolateral membrane targeting signal of human sodium-dependent dicarboxylate transporter 3". J. Cell. Physiol. 206 (3): 821–30. doi:10.1002/jcp.20553. PMID 16331647. S2CID 37471691.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000158296 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000018459 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10794676-5] Wang H, Fei YJ, Kekuda R, Yang-Feng TL, Devoe LD, Leibach FH, Prasad PD, Ganapathy V (Jun 2000). "Structure, function, and genomic organization of human Na(+)-dependent high-affinity dicarboxylate transporter". Am J Physiol Cell Physiol. 278 (5): C1019–30. doi:10.1152/ajpcell.2000.278.5.C1019. PMID 10794676. S2CID 39532742.

[pmid10992006-6] Huang W, Wang H, Kekuda R, Fei YJ, Friedrich A, Wang J, Conway SJ, Cameron RS, Leibach FH, Ganapathy V (Nov 2000). "Transport of N-acetylaspartate by the Na(+)-dependent high-affinity dicarboxylate transporter NaDC3 and its relevance to the expression of the transporter in the brain". J Pharmacol Exp Ther. 295 (1): 392–403. PMID 10992006.

[entrez-7] "Entrez Gene: SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3".

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[5]

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See also

References

Further reading