PSMG1

PSMG1
Identifiers
Aliases	PSMG1, C21LRP, DSCR2, LRPC21, PAC-1, PAC1, proteasome assembly chaperone 1
External IDs	OMIM: 605296; MGI: 1860263; HomoloGene: 2759; GeneCards: PSMG1; OMA:PSMG1 - orthologs
Gene location (Human)
Chr.	Chromosome 21 (human)
End	39,183,488 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	95,792,160 bp
RNA expression pattern
	Top expressed in
	rectum; ; endometrium; ; body of pancreas; ; right adrenal gland; ; islet of Langerhans; ; left adrenal gland; ; anterior pituitary; ; stromal cell of endometrium; ; right lobe of liver; ; gastrocnemius muscle;
	Top expressed in
	otic placode; ; saccule; ; primitive streak; ; endocardial cushion; ; abdominal wall; ; left lobe of liver; ; medial ganglionic eminence; ; yolk sac; ; maxillary prominence; ; somite;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; proteasome binding;
Cellular component	cytoplasm; Golgi apparatus; endoplasmic reticulum; nucleus; nucleoplasm; cytosol;
Biological process	cerebellar granule cell precursor proliferation; proteasome assembly; proteasome core complex assembly;
	Sources:Amigo / QuickGO
Orthologs
	8624
	56088
	ENSG00000183527
	ENSMUSG00000022913
	O95456
	Q9JK23
	NM_001261824; NM_003720; NM_203433; NM_001320795
	NM_019537
	NP_001248753; NP_001307724; NP_003711; NP_982257
	NP_062410
	Wikidata
View/Edit Human	View/Edit Mouse

Proteasome assembly chaperone 1 is a protein that in humans is encoded by the PSMG1 gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000183527 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022913 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Vidal-Taboada JM, Lu A, Pique M, Pons G, Gil J, Oliva R (Jul 2000). "Down syndrome critical region gene 2: expression during mouse development and in human cell lines indicates a function related to cell proliferation". Biochem Biophys Res Commun. 272 (1): 156–63. doi:10.1006/bbrc.2000.2726. PMID 10872820.
^ Hirano Y, Hayashi H, Iemura S, Hendil KB, Niwa S, Kishimoto T, Kasahara M, Natsume T, Tanaka K, Murata S (Dec 2006). "Cooperation of multiple chaperones required for the assembly of mammalian 20S proteasomes". Mol Cell. 24 (6): 977–84. doi:10.1016/j.molcel.2006.11.015. PMID 17189198.
^ "Entrez Gene: DSCR2 Down syndrome critical region gene 2".

Vidal-Taboada JM, Sanz S, Egeo A, et al. (1998). "Identification and characterization of a new gene from human chromosome 21 between markers D21S343 and D21S268 encoding a leucine-rich protein". Biochem. Biophys. Res. Commun. 250 (3): 547–54. doi:10.1006/bbrc.1998.9352. PMID 9784380.
Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Possik PA, Sommer CA, Issa Hori J, et al. (2005). "DSCR2, a Down syndrome critical region protein, is localized to the endoplasmic reticulum of mammalian cells". European Journal of Histochemistry. 48 (3): 267–72. PMID 15590417.
Vesa J, Brown Y, Greenfield D, Korenberg JR (2005). "Molecular and cellular characterization of the Down syndrome critical region protein 2". Biochem. Biophys. Res. Commun. 328 (1): 235–42. doi:10.1016/j.bbrc.2004.09.226. PMID 15670775.
Hirano Y, Hendil KB, Yashiroda H, et al. (2005). "A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes". Nature. 437 (7063): 1381–5. Bibcode:2005Natur.437.1381H. doi:10.1038/nature04106. PMID 16251969. S2CID 4424913.

This article on a gene on human chromosome 21 is a stub. You can help Wikipedia by expanding it.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000183527 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022913 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10872820-5] Vidal-Taboada JM, Lu A, Pique M, Pons G, Gil J, Oliva R (Jul 2000). "Down syndrome critical region gene 2: expression during mouse development and in human cell lines indicates a function related to cell proliferation". Biochem Biophys Res Commun. 272 (1): 156–63. doi:10.1006/bbrc.2000.2726. PMID 10872820.

[pmid17189198-6] Hirano Y, Hayashi H, Iemura S, Hendil KB, Niwa S, Kishimoto T, Kasahara M, Natsume T, Tanaka K, Murata S (Dec 2006). "Cooperation of multiple chaperones required for the assembly of mammalian 20S proteasomes". Mol Cell. 24 (6): 977–84. doi:10.1016/j.molcel.2006.11.015. PMID 17189198.

[entrez-7] "Entrez Gene: DSCR2 Down syndrome critical region gene 2".

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See also

References

Further reading