Myeloid and erythroid nuclear termination stage-specific protein

Myeloid and erythroid nuclear termination stage-specific protein (MENT) is a member of the serpin family of protease inhibitors, and participates in DNA and chromatin condensation.^[1] Alongside its ability to condense chromatin, MENT is also an effective inhibitor of the proteases cathepsin K, cathepsin L, and cathepsin V, all of which are cysteine proteases.^[2] As such, although MENT is structurally classified as a member of the serpin family, it is functionally termed a "cross-class inhibitor," as it is a cysteine rather than a serine protease inhibitor.

References

^ McGowan S, Buckle AM, Irving JA, et al. (July 2006). "X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation". EMBO J. 25 (13): 3144–55. doi:10.1038/sj.emboj.7601201. PMC 1500978. PMID 16810322.
^ Irving JA, Shushanov SS, Pike RN, et al. (April 2002). "Inhibitory activity of a heterochromatin-associated serpin (MENT) against papain-like cysteine proteinases affects chromatin structure and blocks cell proliferation". J. Biol. Chem. 277 (15): 13192–201. doi:10.1074/jbc.M108460200. PMID 11821386.

External links

The MEROPS online database for peptidases and their inhibitors: I04.033

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[1] McGowan S, Buckle AM, Irving JA, et al. (July 2006). "X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation". EMBO J. 25 (13): 3144–55. doi:10.1038/sj.emboj.7601201. PMC 1500978. PMID 16810322.

[2] Irving JA, Shushanov SS, Pike RN, et al. (April 2002). "Inhibitory activity of a heterochromatin-associated serpin (MENT) against papain-like cysteine proteinases affects chromatin structure and blocks cell proliferation". J. Biol. Chem. 277 (15): 13192–201. doi:10.1074/jbc.M108460200. PMID 11821386.

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[2]

v t e Serpins
inhibitory	Alpha 1-antichymotrypsin Alpha 1-antitrypsin Alpha 2-antiplasmin Antithrombin C1-inhibitor Heparin cofactor II Protein C inhibitor Plasminogen activator inhibitor-1 Plasminogen activator inhibitor-2 Protein Z-related protease inhibitor SERPINA1 SERPINA2 SERPINA3 SERPINA4 SERPINA5 SERPINA9 SERPINA14 SERPINB1 SERPINB2 SERPINB3 SERPINB4 SERPINB5 SERPINB6 SERPINB7 SERPINB8 SERPINB9 SERPINB10 SERPINB13 SERPINC1 SERPIND1 SERPINE1 SERPINE2 SERPINE2 SERPINF1 SERPING1 SERPINH1 SERPINI1 SERPINI2
Cross class inhibitory	MENT SCCA-1 CrmA
noninhibitory	Heat shock protein 47 Maspin Ovalbumin Transcortin Thyroxine-binding globulin Angiotensinogen PEDF
see also disorders of globin and globulin proteins