Lactate permease family

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Lactate permease
Lactate permease
Identifiers
Symbol	LctP
Pfam	PF02652
InterPro	IPR003804
TCDB	2.A.14
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

The lactate permease (LctP) family (TC# 2.A.14) is a family of transport proteins belonging to the ion transporter (IT) superfamily.^[1]

Function

Characterized members of this family possess 15-18 transmembrane segments (TMSs) and are roughly 460-565 amino acyl residues in length.

General transport reaction

Transport reactions catalyzed by functionally characterized members of the LctP family include:^[2]

D- or L-lactate or glycolate (out) + H⁺ (out) → D- or L-lactate or glycolate (in) + H⁺ (in).

References

^ Prakash S, Cooper G, Singhi S, Saier MH (December 2003). "The ion transporter superfamily". Biochimica et Biophysica Acta (BBA) - Biomembranes. 1618 (1): 79–92. doi:10.1016/j.bbamem.2003.10.010. PMID 14643936.
^ "2.A.14 The Lactate Permease (LctP) Family". Transporter Classification Database. Retrieved 2016-03-02.

Moraes TF, Reithmeier RA (November 2012). "Membrane transport metabolons". Biochimica et Biophysica Acta (BBA) - Biomembranes. 1818 (11): 2687–706. doi:10.1016/j.bbamem.2012.06.007. PMID 22705263.
Núñez MF, Kwon O, Wilson TH, Aguilar J, Baldoma L, Lin EC (January 2002). "Transport of L-Lactate, D-Lactate, and glycolate by the LldP and GlcA membrane carriers of Escherichia coli". Biochemical and Biophysical Research Communications. 290 (2): 824–9. doi:10.1006/bbrc.2001.6255. PMID 11785976.
Rabus R, Jack DL, Kelly DJ, Saier MH (December 1999). "TRAP transporters: an ancient family of extracytoplasmic solute-receptor-dependent secondary active transporters". Microbiology. 145 (12): 3431–45. doi:10.1099/00221287-145-12-3431. PMID 10627041.
Saier MH, Eng BH, Fard S, Garg J, Haggerty DA, Hutchinson WJ, Jack DL, Lai EC, Liu HJ, Nusinew DP, Omar AM, Pao SS, Paulsen IT, Quan JA, Sliwinski M, Tseng TT, Wachi S, Young GB (February 1999). "Phylogenetic characterization of novel transport protein families revealed by genome analyses". Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes. 1422 (1): 1–56. doi:10.1016/s0304-4157(98)00023-9. PMID 10082980.

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[1] Prakash S, Cooper G, Singhi S, Saier MH (December 2003). "The ion transporter superfamily". Biochimica et Biophysica Acta (BBA) - Biomembranes. 1618 (1): 79–92. doi:10.1016/j.bbamem.2003.10.010. PMID 14643936.

[:0-2] "2.A.14 The Lactate Permease (LctP) Family". Transporter Classification Database. Retrieved 2016-03-02.

[1]

[2]

Function

General transport reaction

References

Further reading