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Formula | C36H40N4O5S |
Molar mass | 640.80 g·mol−1 |
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L-163,491 is an experimental drug which acts as a partial agonist of angiotensin II receptor type 1, and with lower affinity as an agonist of angiotensin II receptor type 2, mimicking the action of angiotensin II.[1] Its practical applications to date have been limited to scientific research into the function of the angiotensin receptor system,[2] but it has been suggested as a potential therapeutic agent for the treatment of inflammation of the lungs associated with certain viral diseases such as COVID-19.[3][4]
References
- ^ De Witt BJ, Garrison EA, Champion HC, Kadowitz PJ (September 2000). "L-163,491 is a partial angiotensin AT(1) receptor agonist in the hindquarters vascular bed of the cat". European Journal of Pharmacology. 404 (1–2): 213–9. doi:10.1016/s0014-2999(00)00612-9. PMID 10980281.
- ^ Alterman M (March 2010). "Development of selective non-peptide angiotensin II type 2 receptor agonists". Journal of the Renin-Angiotensin-Aldosterone System. 11 (1): 57–66. doi:10.1177/1470320309347790. PMID 19880657.
- ^ Liu C, Zhou Q, Li Y, Garner LV, Watkins SP, Carter LJ, et al. (2020). "Research and Development on Therapeutic Agents and Vaccines for COVID-19 and Related Human Coronavirus Diseases". ACS Central Science. 6 (3): 315–331. doi:10.1021/acscentsci.0c00272. PMC 7094090. PMID 32226821.
- ^ Wu Y (February 2020). "Compensation of ACE2 Function for Possible Clinical Management of 2019-nCoV-Induced Acute Lung Injury". Virologica Sinica. 35 (3): 256–258. doi:10.1007/s12250-020-00205-6. PMC 7091449. PMID 32034638.
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