Kinase binding protein CGI-121

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

CGI-121
CGI-121
	crystal structure of pfu-542154 conserved hypothetical protein
Identifiers
Symbol	CGI-121
Pfam	PF08617
InterPro	IPR013926
SCOP2	1zd0 / SCOPe / SUPFAM
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

In molecular biology, the kinase binding protein CGI-121 family of proteins includes the kinase binding protein CGI-121 and its homologues. CGI-121 has been shown to bind to the p53-related protein kinase (PRPK).^[1] CGI-121 is part of a conserved protein complex, KEOPS. The KEOPS complex is involved in telomere uncapping and telomere elongation.^[2] This family of proteins also include archaeal homologues.

References

^ Miyoshi A, Kito K, Aramoto T, Abe Y, Kobayashi N, Ueda N (April 2003). "Identification of CGI-121, a novel PRPK (p53-related protein kinase)-binding protein". Biochem. Biophys. Res. Commun. 303 (2): 399–405. doi:10.1016/S0006-291X(03)00333-4. PMID 12659830.
^ Downey M, Houlsworth R, Maringele L, Rollie A, Brehme M, Galicia S, Guillard S, Partington M, Zubko MK, Krogan NJ, Emili A, Greenblatt JF, Harrington L, Lydall D, Durocher D (March 2006). "A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator". Cell. 124 (6): 1155–68. doi:10.1016/j.cell.2005.12.044. PMID 16564010. S2CID 13928061.

This article incorporates text from the public domain Pfam and InterPro: IPR013926

Zdroj:https://en.wikipedia.org?pojem=Kinase_binding_protein_CGI-121
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[pmid12659830-1] Miyoshi A, Kito K, Aramoto T, Abe Y, Kobayashi N, Ueda N (April 2003). "Identification of CGI-121, a novel PRPK (p53-related protein kinase)-binding protein". Biochem. Biophys. Res. Commun. 303 (2): 399–405. doi:10.1016/S0006-291X(03)00333-4. PMID 12659830.

[pmid16564010-2] Downey M, Houlsworth R, Maringele L, Rollie A, Brehme M, Galicia S, Guillard S, Partington M, Zubko MK, Krogan NJ, Emili A, Greenblatt JF, Harrington L, Lydall D, Durocher D (March 2006). "A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator". Cell. 124 (6): 1155–68. doi:10.1016/j.cell.2005.12.044. PMID 16564010. S2CID 13928061.

[1]

[2]