A | B | C | D | E | F | G | H | CH | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 0 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9
HLA-A23 | |||||||
---|---|---|---|---|---|---|---|
(MHC Class I, A cell surface antigen) | |||||||
![]() HLA-A23 | |||||||
About | |||||||
Protein | transmembrane receptor/ligand | ||||||
Structure | αβ heterodimer | ||||||
Subunits | HLA-A*2301, β2-microglobulin | ||||||
Older names | HL-A9 | ||||||
Subtypes | |||||||
| |||||||
Alleles link-out to IMGT/HLA database at EBI |
HLA-A23 (A23) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α23 subset of HLA-A α-chains. For A23, the alpha, "A", chain are encoded by the HLA-A*23 allele group and the β-chain are encoded by B2M locus.[1] This group currently is dominated by A*2301. A23 and A*23 are almost synonymous in meaning. A23 is a split antigen of the broad antigen HLA-A9 and it is a sister serotype of HLA-A24.
A23 is common in Africa and regions of the Middle East, Mediterranean, and India than Europe, East Asia or the Americas.
Serotype
A*23 | A23 | A24 | Sample |
allele | % | % | size (N) |
*2301 | 95 | 1 | 5119 |
Allele
Study population | Freq. (in %)[3] |
---|---|
Mali Bandiagara | 22.8 |
Cameroon Yaounde | 18.7 |
Senegal Niokholo Mandenka | 17.7 |
Guinea Bissau | 15.6 |
Cameroon Bamileke | 14.9 |
Cape Verde Southeastern I… | 14.8 |
Cameroon Beti | 13.5 |
Zimbabwe Harare Shona | 12.7 |
USA African America | 11.1 |
Portugal North | 10.9 |
South African Natal Zulu | 10.0 |
Cuban Mulatto | 9.5 |
Tunisia | 9.4 |
Kenya Luo | 8.9 |
Morocco Berber Nador Meta… | 8.2 |
Zambia Lusaka | 8.1 |
China Beijing | 7.5 |
Kenya Nandi | 7.1 |
Uganda Kampala | 6.8 |
Georgia Tbilisi Kurds | 6.7 |
Portugal South | 6.1 |
Sudanese | 5.8 |
Bulgaria | 5.5 |
Israel Arab Druse | 5.5 |
Saudi Arabia Guraiat and … | 5.4 |
Spain Catalonia Girona | 4.6 |
Kenya | 4.5 |
Venezuela Caracus | 4.0 |
USA South Texas Hispanics | 3.9 |
Mexico Mestizos | 3.7 |
Russia Tuva pop 2 | 2.9 |
Romanian | 2.5 |
Croatia | 2.3 |
Brazil | 2.0 |
Spain Basque Gipuzkoa Pro… | 2.0 |
Australia New South Wales | 1.9 |
Czech Republic | 1.9 |
Georgia Tbilisi Georgian… | 1.9 |
Oman | 1.7 |
Belgium | 1.6 |
USA North American Native… | 1.6 |
China Inner Mongolia | 1.5 |
India New Delhi | 1.5 |
Pakistan Pathan | 1.5 |
Ireland Northern | 1.4 |
Jordan Amman | 1.4 |
Mongolia Buriat | 1.4 |
Pakistan Sindhi | 1.3 |
USA Caucasian (2) | 1.3 |
France South East | 1.2 |
Italy North Pavia | 1.2 |
Iran Baloch | 1.1 |
Italy Bergamo | 1.1 |
France Corsica | 1.0 |
India North Hindus | 1.0 |
Portugal Centre | 1.0 |
Allele frequencies presented, only |
Haplotypes
A23-B7 is found in N.Afr. and S.Afr non-caucasians.
A23-B44 is found in Albania, Zimbabwe, Morocco, Spain and Danes.
A23-B58 is found in the !kung and Zaire.
Associated diseases
A*23:Cw*07 is associated with higher viral load in HIV[4]
References
- ^ Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 (2): 96–112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067.
- ^ Allele Query Form IMGT/HLA - European Bioinformatics Institute
- ^ Middleton, D.; Menchaca, L.; Rood, H.; Komerofsky, R. (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–407. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.
- ^ Tang J, Tang S, Lobashevsky E, Myracle A, Fideli U, Aldrovandi G, Allen S, Musonda R, Kaslow R (2002). "Favorable and unfavorable HLA class I alleles and haplotypes in Zambians predominantly infected with clade C human immunodeficiency virus type 1". J Virol. 76 (16): 8276–84. doi:10.1128/JVI.76.16.8276-8284.2002. PMC 155130. PMID 12134033.
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