English: Susan Lindquist has transformed our understanding of how protein folding shapes biological systems. She has made ground-breaking contributions in genetics, cell biology and biochemistry, using organisms as diverse as fungi, fruit flies, mustard plants, and mammals. She discovered the functions of heat-shock proteins, identified prions as conduits of protein-based inheritance, and pioneered new platforms for neurodegenerative disease. She established the key role of the heat-shock proteins in tumor progression and the evolution of fungal drug resistance. She discovered that protein-folding buffers and releases genetic variation in response to environmental stress, providing the first plausible explanation for rapid bursts of evolution.

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