Examples of in vitro transdifferentiation by initial epigenetic activation phase approach

List:^[1]

Human dermal fibroblasts → multilineage blood progenitors (Oct4 and cytokine treatment)^[2]
Mouse dermal fibroblasts → polygonal hyaline chondrogenic cells (Klf4, c-Myc, Sox9)^[3]
Mouse dermal fibroblasts → cardiomyocytes (Oct4, Sox2, Klf4, JI1 and Bmp4)^[4]
Fibroblasts → neural stem/progenitor cells (Oct4, Sox2, c-Myc, Klf4)^[5]

References

^ Pournasr, B.; Khaloughi, K.; Salekdeh, G. H.; Totonchi, M.; Shahbazi, E.; Baharvand, H. (2011). "Concise Review: Alchemy of Biology: Generating Desired Cell Types from Abundant and Accessible Cells". Stem Cells. 29 (12): 1933–1941. doi:10.1002/stem.760. PMID 21997905.
^ Szabo, E.; Rampalli, S.; Risueño, R. M.; Schnerch, A.; Mitchell, R.; Fiebig-Comyn, A.; Levadoux-Martin, M.; Bhatia, M. (2010). "Direct conversion of human fibroblasts to multilineage blood progenitors". Nature. 468 (7323): 521–526. doi:10.1038/nature09591. PMID 21057492. S2CID 205223078.
^ Hiramatsu, K.; Sasagawa, S.; Outani, H.; Nakagawa, K.; Yoshikawa, H.; Tsumaki, N. (2011). "Generation of hyaline cartilaginous tissue from mouse adult dermal fibroblast culture by defined factors". Journal of Clinical Investigation. 121 (2): 640–657. doi:10.1172/JCI44605. PMC 3026734. PMID 21293062.
^ Efe, J. A.; Hilcove, S.; Kim, J.; Zhou, H.; Ouyang, K.; Wang, G.; Chen, J.; Ding, S. (2011). "Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy". Nature Cell Biology. 13 (3): 215–222. doi:10.1038/ncb2164. PMID 21278734. S2CID 5310172.
^ Kim, J.; Efe, J. A.; Zhu, S.; Talantova, M.; Yuan, X.; Wang, S.; Lipton, S. A.; Zhang, K.; Ding, S. (2011). "Direct reprogramming of mouse fibroblasts to neural progenitors". Proceedings of the National Academy of Sciences. 108 (19): 7838–7843. doi:10.1073/pnas.1103113108. PMC 3093517. PMID 21521790.

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[1] Pournasr, B.; Khaloughi, K.; Salekdeh, G. H.; Totonchi, M.; Shahbazi, E.; Baharvand, H. (2011). "Concise Review: Alchemy of Biology: Generating Desired Cell Types from Abundant and Accessible Cells". Stem Cells. 29 (12): 1933–1941. doi:10.1002/stem.760. PMID 21997905.

[2] Szabo, E.; Rampalli, S.; Risueño, R. M.; Schnerch, A.; Mitchell, R.; Fiebig-Comyn, A.; Levadoux-Martin, M.; Bhatia, M. (2010). "Direct conversion of human fibroblasts to multilineage blood progenitors". Nature. 468 (7323): 521–526. doi:10.1038/nature09591. PMID 21057492. S2CID 205223078.

[3] Hiramatsu, K.; Sasagawa, S.; Outani, H.; Nakagawa, K.; Yoshikawa, H.; Tsumaki, N. (2011). "Generation of hyaline cartilaginous tissue from mouse adult dermal fibroblast culture by defined factors". Journal of Clinical Investigation. 121 (2): 640–657. doi:10.1172/JCI44605. PMC 3026734. PMID 21293062.

[4] Efe, J. A.; Hilcove, S.; Kim, J.; Zhou, H.; Ouyang, K.; Wang, G.; Chen, J.; Ding, S. (2011). "Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy". Nature Cell Biology. 13 (3): 215–222. doi:10.1038/ncb2164. PMID 21278734. S2CID 5310172.

[5] Kim, J.; Efe, J. A.; Zhu, S.; Talantova, M.; Yuan, X.; Wang, S.; Lipton, S. A.; Zhang, K.; Ding, S. (2011). "Direct reprogramming of mouse fibroblasts to neural progenitors". Proceedings of the National Academy of Sciences. 108 (19): 7838–7843. doi:10.1073/pnas.1103113108. PMC 3093517. PMID 21521790.

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[2]

[3]

[4]

[5]

See also

References