A | B | C | D | E | F | G | H | CH | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 0 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9
Epstein–Barr virus latent membrane protein 1 (LMP1) is an Epstein–Barr virus (EBV) protein that regulates its own expression and the expression of human genes.[1] It has a molecular weight of approximately 63 kDa, and its expression induces many of the changes associated with EBV infections and activation of primary B cells.[2] LMP1 is the best-documented oncoprotein of the EBV latent gene products, as it is expressed in most EBV-related human cancers[3] such as the various malignant Epstein-Barr virus-associated lymphoproliferative diseases.[4]
The structure of LMP1 consists of a short cytoplasmic terminal tail, six trans-membrane domains, and a long cytoplasmic C-terminus, which contains three activating domains: CTARt, CTAR2, and CTAR3. Each CTAR domain contains an amino acid sequence that serves as a recognition site for cellular adaptors to bind and trigger a series of signal transduction pathways that can lead to a change in gene expression.[5]
LMP-1 is a functional homologue of tumor necrosis factor[6] and mediates signaling through the nuclear factor-κB pathway, mimicking CD40 receptor signaling.[1][3]
It is often found in the malignant Reed–Sternberg cells of Hodgkin lymphoma,[7][8] the malignant B cells of EBV-associated B cell lymphatic cancers, and the malignant NK cells of NK/T cell lymphatic cancers.[4]
References
- ^ a b Pratt, Z; Zhang, J; Sugden, B. (2012). "The latent membrane protein 1 (LMP1) oncogene of Epstein–Barr virus can simultaneously induce and inhibit apoptosis in B cells". Journal of Virology. 86 (8): 4380–4393. doi:10.1128/JVI.06966-11. PMC 3318665. PMID 22318153.
- ^ Gupta (2011). "Latent Membrane Protein 1 as a molecular adjuvant for single-cycle lentiviral vaccines". Retrovirology. 8 (1): 39. doi:10.1186/1742-4690-8-39. PMC 3118346. PMID 21592361.
- ^ a b Ersing, I; Bernhardt, K; Gewurz, BE (Jun 21, 2013). "NF-κB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1". Viruses. 5 (6) (6 ed.): 1587–606. doi:10.3390/v5061587. PMC 3717723. PMID 23793113.
- ^ a b Rezk SA, Zhao X, Weiss LM (June 2018). "Epstein - Barr virus - associated lymphoid proliferations, a 2018 update". Human Pathology. 79: 18–41. doi:10.1016/j.humpath.2018.05.020. PMID 29885408. S2CID 47010934.
- ^ Li, H.; Chang, Y. (2003). "Epstein–barr virus latent membrane protein 1: Structure and functions". J. Biomed. Sci. 10 (5): 490–504. doi:10.1159/000072376. PMID 12928589. S2CID 202646382.
- ^ Cameron, J. E.; Yin, Q; Fewell, C; Lacey, M; McBride, J; Wang, X; Lin, Z; Schaefer, B. C.; Flemington, E. K. (2008). "Epstein-Barr virus latent membrane protein 1 induces cellular MicroRNA miR-146a, a modulator of lymphocyte signaling pathways". Journal of Virology. 82 (4): 1946–58. doi:10.1128/JVI.02136-07. PMC 2258704. PMID 18057241.
- ^ Herling M, Rassidakis GZ, Medeiros LJ, et al. (June 2003). "Expression of Epstein–Barr virus latent membrane protein-1 in Hodgkin and Reed-Sternberg cells of classical Hodgkin's lymphoma: associations with presenting features, serum interleukin 10 levels, and clinical outcome". Clin. Cancer Res. 9 (6): 2114–20. PMID 12796376.
- ^ Andersson J (May 2006). "Epstein–Barr virus and Hodgkin's lymphoma". Herpes. 13 (1): 12–6. PMID 16732997.
Text je dostupný za podmienok Creative Commons Attribution/Share-Alike License 3.0 Unported; prípadne za ďalších podmienok. Podrobnejšie informácie nájdete na stránke Podmienky použitia.
Antropológia
Aplikované vedy
Bibliometria
Dejiny vedy
Encyklopédie
Filozofia vedy
Forenzné vedy
Humanitné vedy
Knižničná veda
Kryogenika
Kryptológia
Kulturológia
Literárna veda
Medzidisciplinárne oblasti
Metódy kvantitatívnej analýzy
Metavedy
Metodika
Text je dostupný za podmienok Creative
Commons Attribution/Share-Alike License 3.0 Unported; prípadne za ďalších
podmienok.
Podrobnejšie informácie nájdete na stránke Podmienky
použitia.
www.astronomia.sk | www.biologia.sk | www.botanika.sk | www.dejiny.sk | www.economy.sk | www.elektrotechnika.sk | www.estetika.sk | www.farmakologia.sk | www.filozofia.sk | Fyzika | www.futurologia.sk | www.genetika.sk | www.chemia.sk | www.lingvistika.sk | www.politologia.sk | www.psychologia.sk | www.sexuologia.sk | www.sociologia.sk | www.veda.sk I www.zoologia.sk