A | B | C | D | E | F | G | H | CH | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 0 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9
Diacylglycerol kinase theta is an enzyme that in humans is encoded by the DGKQ gene.[5][6][7]
The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction.[7]
Interactions
DGKQ has been shown to interact with RHOA.[8]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000145214 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004815 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Endele S, Zabel B, Winterpacht A (Jun 1996). "Assignment of the human diacylglycerol kinase 4 (DAGK4) gene to chromosome 4p16.3". Genomics. 33 (1): 145–6. doi:10.1006/geno.1996.0174. PMID 8617502.
- ^ Houssa B, Schaap D, van der Wal J, Goto K, Kondo H, Yamakawa A, Shibata M, Takenawa T, van Blitterswijk WJ (May 1997). "Cloning of a novel human diacylglycerol kinase (DGKtheta) containing three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain". J Biol Chem. 272 (16): 10422–8. doi:10.1074/jbc.272.16.10422. PMID 9099683.
- ^ a b "Entrez Gene: DGKQ diacylglycerol kinase, theta 110kDa".
- ^ Houssa, B; de Widt J; Kranenburg O; Moolenaar W H; van Blitterswijk W J (Mar 1999). "Diacylglycerol kinase theta binds to and is negatively regulated by active RhoA". J. Biol. Chem. 274 (11): 6820–2. doi:10.1074/jbc.274.11.6820. ISSN 0021-9258. PMID 10066731.
Further reading
- Sakane F, Kanoh H (1998). "Molecules in focus: diacylglycerol kinase". Int. J. Biochem. Cell Biol. 29 (10): 1139–43. doi:10.1016/S1357-2725(97)00037-X. PMID 9438377.
- Li D, Urs AN, Allegood J, et al. (2008). "Cyclic AMP-Stimulated Interaction between Steroidogenic Factor 1 and Diacylglycerol Kinase θ Facilitates Induction of CYP17". Mol. Cell. Biol. 27 (19): 6669–85. doi:10.1128/MCB.00355-07. PMC 2099220. PMID 17664281.
- van Baal J, de Widt J, Divecha N, van Blitterswijk WJ (2005). "Translocation of diacylglycerol kinase theta from cytosol to plasma membrane in response to activation of G protein-coupled receptors and protein kinase C". J. Biol. Chem. 280 (11): 9870–8. doi:10.1074/jbc.M409301200. PMID 15632189.
- Tabellini G, Bortul R, Santi S, et al. (2003). "Diacylglycerol kinase-theta is localized in the speckle domains of the nucleus". Exp. Cell Res. 287 (1): 143–54. doi:10.1016/S0014-4827(03)00115-0. PMID 12799190.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Houssa B, de Widt J, Kranenburg O, et al. (1999). "Diacylglycerol kinase theta binds to and is negatively regulated by active RhoA". J. Biol. Chem. 274 (11): 6820–2. doi:10.1074/jbc.274.11.6820. PMID 10066731.
- Sakane F, Imai S, Kai M, et al. (1996). "Molecular cloning of a novel diacylglycerol kinase isozyme with a pleckstrin homology domain and a C-terminal tail similar to those of the EPH family of protein-tyrosine kinases". J. Biol. Chem. 271 (14): 8394–401. doi:10.1074/jbc.271.14.8394. PMID 8626538.
Text je dostupný za podmienok Creative Commons Attribution/Share-Alike License 3.0 Unported; prípadne za ďalších podmienok. Podrobnejšie informácie nájdete na stránke Podmienky použitia.
Antropológia
Aplikované vedy
Bibliometria
Dejiny vedy
Encyklopédie
Filozofia vedy
Forenzné vedy
Humanitné vedy
Knižničná veda
Kryogenika
Kryptológia
Kulturológia
Literárna veda
Medzidisciplinárne oblasti
Metódy kvantitatívnej analýzy
Metavedy
Metodika
Text je dostupný za podmienok Creative
Commons Attribution/Share-Alike License 3.0 Unported; prípadne za ďalších
podmienok.
Podrobnejšie informácie nájdete na stránke Podmienky
použitia.
www.astronomia.sk | www.biologia.sk | www.botanika.sk | www.dejiny.sk | www.economy.sk | www.elektrotechnika.sk | www.estetika.sk | www.farmakologia.sk | www.filozofia.sk | Fyzika | www.futurologia.sk | www.genetika.sk | www.chemia.sk | www.lingvistika.sk | www.politologia.sk | www.psychologia.sk | www.sexuologia.sk | www.sociologia.sk | www.veda.sk I www.zoologia.sk