CRYZL1

CRYZL1
Identifiers
Aliases	CRYZL1, 4P11, QOH-1, crystallin zeta like 1
External IDs	OMIM: 603920; MGI: 1913859; HomoloGene: 3749; GeneCards: CRYZL1; OMA:CRYZL1 - orthologs
Gene location (Human)
Chr.	Chromosome 21 (human)
End	33,643,926 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	91,525,863 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; gastric mucosa; ; popliteal artery; ; tibial arteries; ; muscle layer of sigmoid colon; ; ventricular zone; ; Descending thoracic aorta; ; anterior cingulate cortex; ; left ovary; ; amygdala;
	Top expressed in
	sciatic nerve; ; dentate gyrus of hippocampal formation granule cell; ; Region I of hippocampus proper; ; superior frontal gyrus; ; medial ganglionic eminence; ; cerebellar cortex; ; renal corpuscle; ; primary visual cortex; ; Paneth cell; ; epithelium of lens;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity; NADP binding; NADPH:quinone reductase activity;
Cellular component	cytosol;
Biological process	quinone metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	9946
	66609
	ENSG00000205758
	ENSMUSG00000058240
	O95825
	Q921W4
	NM_145858; NM_145311
	NM_026994; NM_133679
	NP_665857
	NP_081270; NP_598440
	Wikidata
View/Edit Human	View/Edit Mouse

Quinone oxidoreductase-like protein 1 is an enzyme that in humans is encoded by the CRYZL1 gene.^[5]^[6]

This gene encodes a protein that has sequence similarity to zeta crystallin, also known as quinone oxidoreductase. This zeta crystallin-like protein also contains an NAD(P)H binding site. Alternatively spliced transcript variants have been observed but their full-length nature has not been completely determined.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000205758 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000058240 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kim MY, Lee HK, Park JS, Park SH, Kwon HB, Soh J (Jun 1999). "Identification of a zeta-crystallin (quinone reductase)-like 1 gene (CRYZL1) mapped to human chromosome 21q22.1". Genomics. 57 (1): 156–9. doi:10.1006/geno.1998.5714. PMID 10191096.
^ ^a ^b "Entrez Gene: CRYZL1 crystallin, zeta (quinone reductase)-like 1".

External links

Human CRYZL1 genome location and CRYZL1 gene details page in the UCSC Genome Browser.

Mount SM (2000). "Genomic Sequence, Splicing, and Gene Annotation". Am. J. Hum. Genet. 67 (4): 788–92. doi:10.1086/303098. PMC 1287883. PMID 10986039.
Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Hu YH, Warnatz HJ, Vanhecke D, et al. (2006). "Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins". BMC Genomics. 7: 155. doi:10.1186/1471-2164-7-155. PMC 1526728. PMID 16780588.
Fernández MR, Porté S, Crosas E, et al. (2007). "Human and yeast zeta-crystallins bind AU-rich elements in RNA". Cell. Mol. Life Sci. 64 (11): 1419–27. doi:10.1007/s00018-007-7091-1. PMC 11136237. PMID 17497241. S2CID 2165411.

This article on a gene on human chromosome 21 is a stub. You can help Wikipedia by expanding it.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000205758 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000058240 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10191096-5] Kim MY, Lee HK, Park JS, Park SH, Kwon HB, Soh J (Jun 1999). "Identification of a zeta-crystallin (quinone reductase)-like 1 gene (CRYZL1) mapped to human chromosome 21q22.1". Genomics. 57 (1): 156–9. doi:10.1006/geno.1998.5714. PMID 10191096.

[entrez-6] "Entrez Gene: CRYZL1 crystallin, zeta (quinone reductase)-like 1".

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References

External links

Further reading