CDH4

CDH4
Identifiers
Aliases	CDH4, CAD4, R-CAD, RCAD, cadherin 4
External IDs	OMIM: 603006; MGI: 99218; HomoloGene: 48044; GeneCards: CDH4; OMA:CDH4 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	61,940,617 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	179,541,166 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; nucleus accumbens; ; temporal lobe; ; amygdala; ; caudate nucleus; ; putamen; ; prefrontal cortex; ; superior frontal gyrus; ; dorsolateral prefrontal cortex; ; stromal cell of endometrium;
	Top expressed in
	Bowman's capsule; ; saccule; ; coelomic epithelium; ; glomerulus; ; olfactory bulb; ; ganglionic eminence; ; olfactory tubercle; ; paraventricular nucleus of hypothalamus; ; medial dorsal nucleus; ; ventromedial nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; metal ion binding; cytoskeletal protein binding; protein homodimerization activity; cadherin binding;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane; cell surface; catenin complex;
Biological process	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; cell adhesion; positive regulation of axon extension; adherens junction organization; homophilic cell adhesion via plasma membrane adhesion molecules; axon guidance; cell-cell junction assembly; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell-cell adhesion mediated by cadherin; cell-cell adhesion; cell morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	1002
	12561
	ENSG00000280641; ENSG00000179242
	ENSMUSG00000000305
	P55283
	P39038
	NM_001794; NM_001252338; NM_001252339
	NM_009867; NM_001316723
	NP_001239267; NP_001239268; NP_001785
	NP_001303652; NP_033997
	Wikidata
View/Edit Human	View/Edit Mouse

Cadherin-4 is a protein that in humans is encoded by the CDH4 gene.^[5]^[6]^[7]

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization.^[7]

Interactions

Cadherin-4 has been shown to interact with:

PTPmu^[8]

References

^ ^a ^b ^c ENSG00000179242 GRCh38: Ensembl release 89: ENSG00000280641, ENSG00000179242 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000000305 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chalmers IJ, Hofler H, Atkinson MJ (Jun 1999). "Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma". Genomics. 57 (1): 160–3. doi:10.1006/geno.1998.5717. PMID 10191097.
^ Kools P, Vanhalst K, van Roy F (Oct 1999). "Assignment of cadherin-4 (R-cadherin, CDH4) to human chromosome band 20q13.3". Cytogenet Cell Genet. 86 (1): 26–7. doi:10.1159/000015423. PMID 10516427. S2CID 27578498.
^ ^a ^b "Entrez Gene: CDH4 cadherin 4, type 1, R-cadherin (retinal)".
^ Brady-Kalnay SM, Mourton T, Nixon JP, Pietz GE, Kinch M, Chen H, et al. (1998). "Dynamic interaction of PTPmu with multiple cadherins in vivo". J Cell Biol. 141 (1): 287–96. doi:10.1083/jcb.141.1.287. PMC 2132733. PMID 9531566.

External links

CDH4 human gene location in the UCSC Genome Browser.
CDH4 human gene details in the UCSC Genome Browser.

This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by expanding it.

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[refGRCh38Ensembl-1] ENSG00000179242 GRCh38: Ensembl release 89: ENSG00000280641, ENSG00000179242 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000000305 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10191097-5] Chalmers IJ, Hofler H, Atkinson MJ (Jun 1999). "Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma". Genomics. 57 (1): 160–3. doi:10.1006/geno.1998.5717. PMID 10191097.

[pmid10516427-6] Kools P, Vanhalst K, van Roy F (Oct 1999). "Assignment of cadherin-4 (R-cadherin, CDH4) to human chromosome band 20q13.3". Cytogenet Cell Genet. 86 (1): 26–7. doi:10.1159/000015423. PMID 10516427. S2CID 27578498.

[entrez-7] "Entrez Gene: CDH4 cadherin 4, type 1, R-cadherin (retinal)".

[pmid9531566-8] Brady-Kalnay SM, Mourton T, Nixon JP, Pietz GE, Kinch M, Chen H, et al. (1998). "Dynamic interaction of PTPmu with multiple cadherins in vivo". J Cell Biol. 141 (1): 287–96. doi:10.1083/jcb.141.1.287. PMC 2132733. PMID 9531566.

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Interactions

References

Further reading

External links