CD3G

CD3G
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1SY6
Identifiers
Aliases	CD3G, CD3-GAMMA, IMD17, T3G, CD3g molecule, CD3GAMMA, CD3 gamma subunit of T-cell receptor complex
External IDs	OMIM: 186740; MGI: 88333; HomoloGene: 55; GeneCards: CD3G; OMA:CD3G - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	118,355,161 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	44,891,729 bp
RNA expression pattern
	Top expressed in
	lymph node; ; thymus; ; blood; ; appendix; ; superficial temporal artery; ; bone marrow cells; ; spleen; ; rectum; ; gallbladder; ; thymus;
	Top expressed in
	thymus; ; superior surface of tongue; ; gallbladder; ; blood; ; spleen; ; ankle joint; ; subcutaneous adipose tissue; ; duodenum; ; jejunum; ; submandibular gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signaling receptor complex adaptor activity; T cell receptor binding; transmembrane signaling receptor activity; protein heterodimerization activity; protein homodimerization activity;
Cellular component	integral component of membrane; alpha-beta T cell receptor complex; integral component of plasma membrane; T cell receptor complex; membrane; clathrin-coated vesicle membrane; plasma membrane; external side of plasma membrane;
Biological process	protein transport; establishment or maintenance of cell polarity; cell surface receptor signaling pathway; T cell receptor signaling pathway; regulation of lymphocyte apoptotic process; T cell activation; Fc-gamma receptor signaling pathway involved in phagocytosis; regulation of immune response; membrane organization; protein homooligomerization; adaptive immune response; immune system process; protein-containing complex assembly; T cell differentiation; positive thymic T cell selection; positive regulation of signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	917
	12502
	ENSG00000160654
	ENSMUSG00000002033
	P09693
	P11942
	NM_000073
	NM_009850
	NP_000064
	NP_033980
	Wikidata
View/Edit Human	View/Edit Mouse

T-cell surface glycoprotein CD3 gamma chain is a protein that in humans is encoded by the CD3G gene.

T cell antigen receptor (TCR) is associated on the T cell surface with a complex of protein called CD3. CD3G (gamma chain) is one of the four peptides (gamma, delta, epsilon and zeta) that form CD3. Defects in CD3G are associated with T cell immunodeficiency.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000160654 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000002033 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: CD3G CD3g molecule, gamma (CD3-TCR complex)".

Joseph AM, Kumar M, Mitra D (2005). "Nef: "necessary and enforcing factor" in HIV infection". Curr. HIV Res. 3 (1): 87–94. doi:10.2174/1570162052773013. PMID 15638726.
Li CJ (2007). "Therapeutic biology: checkpoint pathway activation therapy, HIV Tat, and transkingdom RNA interference". J. Cell. Physiol. 209 (3): 695–700. doi:10.1002/jcp.20817. PMID 17001685. S2CID 37846031.
Luzzati AL, Giacomini E, Giordani L, et al. (1992). "The antigen-specific induction of normal human lymphocytes in vitro is down-regulated by a conserved HIV p24 epitope". Immunol. Lett. 33 (3): 307–14. doi:10.1016/0165-2478(92)90078-3. PMID 1385321.
Lanier LL, Chang C, Spits H, Phillips JH (1992). "Expression of cytoplasmic CD3 epsilon proteins in activated human adult natural killer (NK) cells and CD3 gamma, delta, epsilon complexes in fetal NK cells. Implications for the relationship of NK and T lymphocytes". J. Immunol. 149 (6): 1876–80. doi:10.4049/jimmunol.149.6.1876. PMID 1387664.
Letourneur F, Klausner RD (1992). "A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains". Cell. 69 (7): 1143–57. doi:10.1016/0092-8674(92)90636-Q. PMID 1535555. S2CID 32641759.
Arnaiz-Villena A, Timon M, Corell A, et al. (1992). "Brief report: primary immunodeficiency caused by mutations in the gene encoding the CD3-gamma subunit of the T-lymphocyte receptor". N. Engl. J. Med. 327 (8): 529–33. doi:10.1056/NEJM199208203270805. PMID 1635567.
Arnaiz-Villena A, Perez-Aciego P, Ballestin C, et al. (1991). "Biochemical basis of a novel T lymphocyte receptor immunodeficiency by immunohistochemistry. A possible CD3 gamma abnormality". Lab. Invest. 64 (5): 675–81. PMID 1709425.
Alarcón B, Ley SC, Sánchez-Madrid F, et al. (1991). "The CD3-gamma and CD3-delta subunits of the T cell antigen receptor can be expressed within distinct functional TCR/CD3 complexes". EMBO J. 10 (4): 903–12. doi:10.1002/j.1460-2075.1991.tb08023.x. PMC 452733. PMID 1826255.
Ruegg CL, Strand M (1991). "A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influx". Cell. Immunol. 137 (1): 1–13. doi:10.1016/0008-8749(91)90051-C. PMID 1832084.
Cefai D, Debre P, Kaczorek M, et al. (1991). "Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway". J. Clin. Invest. 86 (6): 2117–24. doi:10.1172/JCI114950. PMC 329852. PMID 1979339.
Luzzati AL, Pugliese O, Giacomini E, et al. (1990). "Immunoregulatory effect of a synthetic peptide corresponding to a region of protein p24 of HIV". Folia Biol. (Praha). 36 (1): 71–7. PMID 2111780.
Koning F, Maloy WL, Coligan JE (1990). "The implications of subunit interactions for the structure of the T cell receptor-CD3 complex". Eur. J. Immunol. 20 (2): 299–305. doi:10.1002/eji.1830200211. PMID 2138083. S2CID 2180901.
Ruegg CL, Strand M (1990). "Inhibition of protein kinase C and anti-CD3-induced Ca2+ influx in Jurkat T cells by a synthetic peptide with sequence identity to HIV-1 gp41". J. Immunol. 144 (10): 3928–35. doi:10.4049/jimmunol.144.10.3928. PMID 2139676.
Alexander D, Goris J, Marais R, et al. (1989). "Dephosphorylation of the human T lymphocyte CD3 antigen". Eur. J. Biochem. 181 (1): 55–65. doi:10.1111/j.1432-1033.1989.tb14693.x. PMID 2540970.
Griesinger F, Greenberg JM, Kersey JH (1989). "T cell receptor gamma and delta rearrangements in hematologic malignancies. Relationship to lymphoid differentiation". J. Clin. Invest. 84 (2): 506–16. doi:10.1172/JCI114193. PMC 548910. PMID 2547833.
Tunnacliffe A, Buluwela L, Rabbitts TH (1988). "Physical linkage of three CD3 genes on human chromosome 11". EMBO J. 6 (10): 2953–7. doi:10.1002/j.1460-2075.1987.tb02600.x. PMC 553731. PMID 2826124.
Krissansen GW, Owen MJ, Verbi W, Crumpton MJ (1986). "Primary structure of the T3 gamma subunit of the T3/T cell antigen receptor complex deduced from cDNA sequences: evolution of the T3 gamma and delta subunits". EMBO J. 5 (8): 1799–808. doi:10.1002/j.1460-2075.1986.tb04429.x. PMC 1167043. PMID 2944745.
Davies AA, Cantrell DA, Hexham JM, et al. (1987). "The human T3 gamma chain is phosphorylated at serine 126 in response to T lymphocyte activation". J. Biol. Chem. 262 (23): 10918–21. doi:10.1016/S0021-9258(18)60903-2. PMID 3112151.
Gold DP, Clevers H, Alarcon B, et al. (1987). "Evolutionary relationship between the T3 chains of the T-cell receptor complex and the immunoglobulin supergene family". Proc. Natl. Acad. Sci. U.S.A. 84 (21): 7649–53. Bibcode:1987PNAS...84.7649G. doi:10.1073/pnas.84.21.7649. PMC 299357. PMID 3478717.
Oravecz T, Norcross MA (1994). "Costimulatory properties of the human CD4 molecule: enhancement of CD3-induced T cell activation by human immunodeficiency virus type 1 through viral envelope glycoprotein gp120". AIDS Res. Hum. Retroviruses. 9 (10): 945–55. doi:10.1089/aid.1993.9.945. PMID 7506554.

External links

Human CD3G genome location and CD3G gene details page in the UCSC Genome Browser.
Overview of all the structural information available in the PDB for UniProt: P09693 (T-cell surface glycoprotein CD3 gamma chain) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000160654 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000002033 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CD3G CD3g molecule, gamma (CD3-TCR complex)".

[1]

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[3]

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[5]

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

See also

References

Further reading

External links