Asialoglycoprotein

If terminal sialic acid residues are removed from glycoproteins, the resulting proteins are known as asialoglycoproteins.^[1]^[2]

In rats, the exposure of subterminal galactose or GalNAc residues may assist in receptor-mediated endocytosis of asialoglycoproteins by asialoglycoprotein receptors on Kuppfer cells. The human ortholog of this gene is non-functional, but hepatocyte asialoglycoprotein receptors are functional in both humans and rats.^[3]

External links

Asialoglycoproteins at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

References

^ Gross, Hans Jürgen; Brossmer, Reinhard (1987-06-01). "N-Acetyl-4-deoxy-d-neuraminic acid is activated and transferred on to asialoglycoprotein". Glycoconjugate Journal. 4 (2): 145–156. doi:10.1007/BF01049452. ISSN 1573-4986. S2CID 7911178.
^ Regoeczi, E.; Chindemi, P. A. (1981-01-01). "The net weight of the rabbit liver and its relevance for asialoglycoprotein clearance". Growth. 45 (1): 19–28. ISSN 0017-4793. PMID 7227848.
^ Fadden AJ, Holt OJ, Drickamer K (2003). "Molecular characterization of the rat Kupffer cell glycoprotein receptor". Glycobiology. 13 (7): 529–537. doi:10.1093/glycob/cwg068. PMID 12672702.

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[1] Gross, Hans Jürgen; Brossmer, Reinhard (1987-06-01). "N-Acetyl-4-deoxy-d-neuraminic acid is activated and transferred on to asialoglycoprotein". Glycoconjugate Journal. 4 (2): 145–156. doi:10.1007/BF01049452. ISSN 1573-4986. S2CID 7911178.

[2] Regoeczi, E.; Chindemi, P. A. (1981-01-01). "The net weight of the rabbit liver and its relevance for asialoglycoprotein clearance". Growth. 45 (1): 19–28. ISSN 0017-4793. PMID 7227848.

[3] Fadden AJ, Holt OJ, Drickamer K (2003). "Molecular characterization of the rat Kupffer cell glycoprotein receptor". Glycobiology. 13 (7): 529–537. doi:10.1093/glycob/cwg068. PMID 12672702.

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