2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

OHCU decarboxylase
OHCU decarboxylase
Identifiers
Symbol	OHCU_decarbox
Pfam	PF09349
InterPro	IPR018020
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

In molecular biology 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase (OHCU decarboxylase) EC 4.1.1.n1 is an enzyme involved in purine catabolism. It catalyses the decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) into S(+)-allantoin.^[1]^[2] It is the third step of the conversion of uric acid (a purine derivative) to allantoin. Step one is catalysed by urate oxidase and step two is catalysed by hydroxyisourate hydrolase.^[3]^[4]

References

^ Ramazzina I, Folli C, Secchi A, Berni R, Percudani R (March 2006). "Completing the uric acid degradation pathway through phylogenetic comparison of whole genomes". Nat. Chem. Biol. 2 (3): 144–8. doi:10.1038/nchembio768. PMID 16462750. S2CID 13441301.
^ Cendron L, Berni R, Folli C, Ramazzina I, Percudani R, Zanotti G (2007). "The structure of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase provides insights into the mechanism of uric acid degradation". J Biol Chem. 282 (25): 18182–9. doi:10.1074/jbc.M701297200. hdl:11577/1777398. PMID 17428786.
^ Kim K, Park J, Rhee S (2007). "Structural and functional basis for (S)-allantoin formation in the ureide pathway". J Biol Chem. 282 (32): 23457–64. doi:10.1074/jbc.M703211200. PMID 17567580.
^ Todd CD, Tipton PA, Blevins DG, Piedras P, Pineda M, Polacco JC (2006). "Update on ureide degradation in legumes". J Exp Bot. 57 (1): 5–12. doi:10.1093/jxb/erj013. PMID 16317038.

This article incorporates text from the public domain Pfam and InterPro: IPR018020

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[pmid16462750-1] Ramazzina I, Folli C, Secchi A, Berni R, Percudani R (March 2006). "Completing the uric acid degradation pathway through phylogenetic comparison of whole genomes". Nat. Chem. Biol. 2 (3): 144–8. doi:10.1038/nchembio768. PMID 16462750. S2CID 13441301.

[pmid17428786-2] Cendron L, Berni R, Folli C, Ramazzina I, Percudani R, Zanotti G (2007). "The structure of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase provides insights into the mechanism of uric acid degradation". J Biol Chem. 282 (25): 18182–9. doi:10.1074/jbc.M701297200. hdl:11577/1777398. PMID 17428786.

[pmid17567580-3] Kim K, Park J, Rhee S (2007). "Structural and functional basis for (S)-allantoin formation in the ureide pathway". J Biol Chem. 282 (32): 23457–64. doi:10.1074/jbc.M703211200. PMID 17567580.

[pmid16317038-4] Todd CD, Tipton PA, Blevins DG, Piedras P, Pineda M, Polacco JC (2006). "Update on ureide degradation in legumes". J Exp Bot. 57 (1): 5–12. doi:10.1093/jxb/erj013. PMID 16317038.

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