Clobenpropit

Clobenpropit
Clinical data
ATC code	None;
Legal status
Legal status	US: Investigational New Drug;
Identifiers
	IUPAC name N'--1-formamidine;
CAS Number	145231-45-4;
PubChem CID	2790;
IUPHAR/BPS	1223;
ChemSpider	2688;
UNII	RKU631JF4H;
ChEMBL	ChEMBL14690;
CompTox Dashboard (EPA)	DTXSID3043738 ;
Chemical and physical data
Formula	C14H17ClN4S
Molar mass	308.83 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1=CC(=CC=C1CN=C(N)SCCCC2=CN=CN2)Cl;

Clobenpropit is a histamine H₃ receptor antagonist.^[1] It has neuroprotective effects via stimulation of GABA release in brain cells in vitro.^[2]

References

^ Sahlholm K, Nilsson J, Marcellino D, Fuxe K, Arhem P (2007). "The human histamine H3 receptor couples to GIRK channels in Xenopus oocytes". European Journal of Pharmacology. 567 (3): 206–210. doi:10.1016/j.ejphar.2007.04.032. PMID 17537431.
^ Dai H, Fu Q, Shen Y, Hu W, Zhang Z, Timmerman H, Leurs R, Chen Z (2007). "The histamine H3 receptor antagonist clobenpropit enhances GABA release to protect against NMDA-induced excitotoxicity through the cAMP/protein kinase A pathway in cultured cortical neurons". European Journal of Pharmacology. 563 (1–3): 117–123. doi:10.1016/j.ejphar.2007.01.069. PMID 17350613.

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[pmid17537431-1] Sahlholm K, Nilsson J, Marcellino D, Fuxe K, Arhem P (2007). "The human histamine H3 receptor couples to GIRK channels in Xenopus oocytes". European Journal of Pharmacology. 567 (3): 206–210. doi:10.1016/j.ejphar.2007.04.032. PMID 17537431.

[2] Dai H, Fu Q, Shen Y, Hu W, Zhang Z, Timmerman H, Leurs R, Chen Z (2007). "The histamine H3 receptor antagonist clobenpropit enhances GABA release to protect against NMDA-induced excitotoxicity through the cAMP/protein kinase A pathway in cultured cortical neurons". European Journal of Pharmacology. 563 (1–3): 117–123. doi:10.1016/j.ejphar.2007.01.069. PMID 17350613.

[1]

[2]

Clinical data

ATC code	None
Legal status
Legal status	US: Investigational New Drug
Identifiers
IUPAC name N'--1-formamidine
CAS Number	145231-45-4
PubChem CID	2790
IUPHAR/BPS	1223
ChemSpider	2688
UNII	RKU631JF4H
ChEMBL	ChEMBL14690
CompTox Dashboard (EPA)	DTXSID3043738
Chemical and physical data
Formula	C₁₄H₁₇ClN₄S
Molar mass	308.83 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C1=CC(=CC=C1CN=C(N)SCCCC2=CN=CN2)Cl