Afelimomab

Afelimomab
Monoclonal antibody
Type	F(ab')2 fragment
Source	Mouse
Target	TNFα
Clinical data
ATC code	L04AB03 (WHO) ;
Identifiers
CAS Number	156227-98-4 ;
ChemSpider	none;
UNII	6SC756X51V;
KEGG	D07436 ;
	(what is this?) (verify)

Afelimomab (MAK 195F) is an anti-TNFα monoclonal antibody. Administration of afelimomab reduces the concentration of interleukin-6 in patients with sepsis, but reduces mortality only marginally.^[1]^[2]

References

^ Rondon E, Venkataraman R (August 2005). "Afelimomab led to a modest mortality benefit in patients with severe sepsis and elevated interleukin-6 levels". Critical Care. 9 (5): E20. doi:10.1186/cc3798. PMC 1297624. PMID 16277704.
^ Panacek EA, Marshall JC, Albertson TE, Johnson DH, Johnson S, MacArthur RD, et al. (November 2004). "Efficacy and safety of the monoclonal anti-tumor necrosis factor antibody F(ab')2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels". Critical Care Medicine. 32 (11): 2173–82. doi:10.1097/01.CCM.0000145229.59014.6C. PMID 15640628. S2CID 23321488.

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[1] Rondon E, Venkataraman R (August 2005). "Afelimomab led to a modest mortality benefit in patients with severe sepsis and elevated interleukin-6 levels". Critical Care. 9 (5): E20. doi:10.1186/cc3798. PMC 1297624. PMID 16277704.

[2] Panacek EA, Marshall JC, Albertson TE, Johnson DH, Johnson S, MacArthur RD, et al. (November 2004). "Efficacy and safety of the monoclonal anti-tumor necrosis factor antibody F(ab')2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels". Critical Care Medicine. 32 (11): 2173–82. doi:10.1097/01.CCM.0000145229.59014.6C. PMID 15640628. S2CID 23321488.

[1]

[2]

Monoclonal antibody
Type	F(ab')₂ fragment
Source	Mouse
Target	TNFα
Clinical data
ATC code	L04AB03 (WHO)
Identifiers
CAS Number	156227-98-4^N
ChemSpider	none
UNII	6SC756X51V
KEGG	D07436^Y
^NY (what is this?) (verify)